Klotho‐mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments

Senescent microenvironments play an important role in tumor progression. Here, we report that doxorubicin (DOX)‐pretreated or replicative senescent stromal cells (WI‐38 and HUVEC) promote colorectal cancer (CRC) cell growth and invasion in vitro and in vivo. These pro‐tumorigenic effects were attenu...

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Detalles Bibliográficos
Autores principales: Liu, Yangyang, Pan, Jie, Pan, Xia, Wu, Lunpo, Bian, Jun, Lin, Zhenghua, Xue, Meng, Su, Tingting, Lai, Sanchuan, Chen, Fei, Ge, Qiwei, Chen, Luyi, Ye, Shufang, Zhu, Yabi, Chen, Shujie, Wang, Liangjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822285/
https://www.ncbi.nlm.nih.gov/pubmed/31545552
http://dx.doi.org/10.1002/1878-0261.12577

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