Role of non-macrophage cell-derived HMGB1 in oxaliplatin-induced peripheral neuropathy and its prevention by the thrombin/thrombomodulin system in rodents: negative impact of anticoagulants

BACKGROUND: Macrophage-derived high mobility group box 1 (HMGB1), a damage-associated molecular pattern (DAMP) protein, plays a key role in the development of chemotherapy-induced peripheral neuropathy (CIPN) caused by paclitaxel in rodents. Endothelial thrombomodulin (TM) promotes thrombin-induced...

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Detalles Bibliográficos
Autores principales: Tsubota, Maho, Fukuda, Ryotaro, Hayashi, Yusuke, Miyazaki, Takaya, Ueda, Shin, Yamashita, Rika, Koike, Nene, Sekiguchi, Fumiko, Wake, Hidenori, Wakatsuki, Shuji, Ujiie, Yuka, Araki, Toshiyuki, Nishibori, Masahiro, Kawabata, Atsufumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822350/
https://www.ncbi.nlm.nih.gov/pubmed/31666085
http://dx.doi.org/10.1186/s12974-019-1581-6

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