Cargando…

Club cell protein 16 in sera from trauma patients modulates neutrophil migration and functionality via CXCR1 and CXCR2

BACKGROUND: Club Cell protein (CC)16 correlates with lung injury and respiratory complications, which are in part triggered by polymorphonuclear leukocytes (PMNL) in severely traumatized patients (TP). CC16 exerts anti-inflammatory and immunosuppressive effects, however, its influence on PMNL functi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Baolin, Janicova, Andrea, Vollrath, Jan Tilmann, Störmann, Philipp, Martin, Lukas, Marzi, Ingo, Wutzler, Sebastian, Hildebrand, Frank, Ehnert, Sabrina, Relja, Borna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822417/ https://www.ncbi.nlm.nih.gov/pubmed/31666007 http://dx.doi.org/10.1186/s10020-019-0115-0

Ejemplares similares

Early Local Inhibition of Club Cell Protein 16 Following Chest Trauma Reduces Late Sepsis-Induced Acute Lung Injury
por: Störmann, Philipp, et al.
Publicado: (2019)

Endogenous Uteroglobin as Intrinsic Anti-inflammatory Signal Modulates Monocyte and Macrophage Subsets Distribution Upon Sepsis Induced Lung Injury
por: Janicova, Andrea, et al.
Publicado: (2019)

Club Cell Protein 16 Attenuates CD16(bright)CD62(dim) Immunosuppressive Neutrophils in Damaged Tissue upon Posttraumatic Sepsis-Induced Lung Injury
por: Becker, Nils, et al.
Publicado: (2021)

Early local neutralization of CC16 in sepsis-induced ALI following blunt chest trauma leads to delayed mortality without benefitting overall survival
por: Vollrath, Jan Tilmann, et al.
Publicado: (2020)

Club cell protein (CC)16 as potential lung injury marker in a porcine 72 h polytrauma model
por: Greven, Johannes, et al.
Publicado: (2022)

Sera from severe trauma patients with pneumonia and without infectious complications have differential effects on neutrophil biology
por: Relja, B., et al.
Publicado: (2016)

Acute alcohol consumption increases systemic endotoxin bioactivity for days in healthy volunteers—with reduced intestinal barrier loss in female
por: Sturm, Ramona, et al.
Publicado: (2021)

Alterations of Phagocytic Activity and Capacity in Granulocytes and Monocytes Depend on the Pathogen Strain in Porcine Polytrauma
por: Vollrath, Jan Tilmann, et al.
Publicado: (2021)

Lung failure after polytrauma with concomitant thoracic trauma in the elderly: an analysis from the TraumaRegister DGU®
por: Vollrath, Jan Tilmann, et al.
Publicado: (2022)

Severe Traumatic Injury Induces Phenotypic and Functional Changes of Neutrophils and Monocytes
por: Janicova, Andrea, et al.
Publicado: (2021)

Post-Traumatic Sepsis Is Associated with Increased C5a and Decreased TAFI Levels
por: Vollrath, Jan Tilmann, et al.
Publicado: (2020)

CXCR4 and CXCR7 Inhibition Ameliorates the Formation of Platelet–Neutrophil Complexes and Neutrophil Extracellular Traps through Adora2b Signaling
por: Ngamsri, Kristian-Christos, et al.
Publicado: (2021)

Danger signals in trauma
por: Relja, Borna, et al.
Publicado: (2018)

I-FABP as a Potential Marker for Intestinal Barrier Loss in Porcine Polytrauma
por: Vollrath, Jan Tilmann, et al.
Publicado: (2022)

Reduced phagocytosis, ROS production and enhanced apoptosis of leukocytes upon alcohol drinking in healthy volunteers
por: Haag, Florian, et al.
Publicado: (2021)

Ethyl Pyruvate Reduces Systemic Leukocyte Activation via Caspase-1 and NF-κB After Blunt Chest Trauma and Haemorrhagic Shock
por: Dieteren, Scott, et al.
Publicado: (2020)

miR-142-3p Expression Is Predictive for Severe Traumatic Brain Injury (TBI) in Trauma Patients
por: Schindler, Cora Rebecca, et al.
Publicado: (2020)

Cytokines in Inflammatory Disease
por: Kany, Shinwan, et al.
Publicado: (2019)

Is I-FABP not only a marker for the detection abdominal injury but also of hemorrhagic shock in severely injured trauma patients?
por: Voth, Maika, et al.
Publicado: (2019)

A nationwide fluidics biobank of polytraumatized patients: implemented by the Network “Trauma Research” (NTF) as an expansion to the TraumaRegister DGU(®) of the German Trauma Society (DGU)
por: Relja, Borna, et al.
Publicado: (2019)

Innate Immunity and Alcohol
por: Kany, Shinwan, et al.
Publicado: (2019)

Acute Alcohol Intoxication Modulates Monocyte Subsets and Their Functions in a Time-Dependent Manner in Healthy Volunteers
por: Janicova, Andrea, et al.
Publicado: (2021)

CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice
por: Mattos, Matheus Silverio, et al.
Publicado: (2020)

Trauma Severity and Its Impact on Local Inflammation in Extremity Injury—Insights From a Combined Trauma Model in Pigs
por: Horst, Klemens, et al.
Publicado: (2020)

Circulating Leukotriene B4 Identifies Respiratory Complications after Trauma
por: Auner, Birgit, et al.
Publicado: (2012)

Circulating Extracellular Vesicles and Their miR “Barcode” Differentiate Alcohol Drinkers With Liver Injury and Those Without Liver Injury in Severe Trauma Patients
por: Eguchi, Akiko, et al.
Publicado: (2019)

Pneumonia in severely injured patients with thoracic trauma: results of a retrospective observational multi-centre study
por: Wutzler, Sebastian, et al.
Publicado: (2019)

Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration
por: Hu, Nan, et al.
Publicado: (2011)

The Role of CXCR1, CXCR2, CXCR3, CXCR5, and CXCR6 Ligands in Molecular Cancer Processes and Clinical Aspects of Acute Myeloid Leukemia (AML)
por: Korbecki, Jan, et al.
Publicado: (2023)

Short Exposure to Ethanol Diminishes Caspase-1 and ASC Activation in Human HepG2 Cells In Vitro
por: Hörauf, Jason-Alexander, et al.
Publicado: (2020)

Microbiome-mediated neutrophil recruitment via CXCR2 and protection from amebic colitis
por: Watanabe, Koji, et al.
Publicado: (2017)

Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase
por: Gong, Lei, et al.
Publicado: (2013)

Impaired Surface Expression of HLA-DR, TLR2, TLR4, and TLR9 in Ex Vivo-In Vitro Stimulated Monocytes from Severely Injured Trauma Patients
por: Heftrig, David, et al.
Publicado: (2017)

CXCR4, the master regulator of neutrophil trafficking in homeostasis and disease
por: De Filippo, Katia, et al.
Publicado: (2018)

CXCR2 intrinsically drives the maturation and function of neutrophils in mice
por: Delobel, Pauline, et al.
Publicado: (2022)

n-butanol extract from Folium isatidis inhibits the lipopolysaccharide-induced downregulation of CXCR1 and CXCR2 on human neutrophils
por: Wu, Beibei, et al.
Publicado: (2018)

CXCR4(hi) effector neutrophils in sickle cell anemia: potential role for elevated circulating serotonin (5-HT) in CXCR4(hi) neutrophil polarization
por: Garcia, Flavia, et al.
Publicado: (2020)

Bone cement implantation syndrome in cemented hip hemiarthroplasty—a persistent risk
por: Weingärtner, Karoline, et al.
Publicado: (2021)

Regulatory T Cells Modulate CD4 Proliferation after Severe Trauma via IL-10
por: Sturm, Ramona, et al.
Publicado: (2020)

Computer‐aided assessment of the chemokine receptors CXCR3, CXCR4 and CXCR7 expression in gallbladder carcinoma
por: Yu, Xiao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7udka6f8ci1cr0ptebhmp4km9l