Associations of BAFF rs2893321 polymorphisms with myasthenia gravis susceptibility

BACKGROUND: Myasthenia gravis (MG) is an autoimmune diseases characterized by fatigue and weakness of skeletal muscles. B-lymphocyte-activating factor (BAFF), an essential factor for B cell differentiation and development, is important in the progression of MG. The current study aimed to investigate...

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Autores principales: Deng, Hui, Wang, Jianjian, Kong, Xiaotong, Zhang, Huixue, Wang, Tianfeng, Tian, Wenqi, Yi, Tingting, Wang, Lihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822419/
https://www.ncbi.nlm.nih.gov/pubmed/31666013
http://dx.doi.org/10.1186/s12881-019-0906-8
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author Deng, Hui
Wang, Jianjian
Kong, Xiaotong
Zhang, Huixue
Wang, Tianfeng
Tian, Wenqi
Yi, Tingting
Wang, Lihua
author_facet Deng, Hui
Wang, Jianjian
Kong, Xiaotong
Zhang, Huixue
Wang, Tianfeng
Tian, Wenqi
Yi, Tingting
Wang, Lihua
author_sort Deng, Hui
collection PubMed
description BACKGROUND: Myasthenia gravis (MG) is an autoimmune diseases characterized by fatigue and weakness of skeletal muscles. B-lymphocyte-activating factor (BAFF), an essential factor for B cell differentiation and development, is important in the progression of MG. The current study aimed to investigate the association between single nucleotide polymorphism rs2893321 in BAFF with MG susceptibility in Chinese Han population. METHODS: One hundred forty-nine patients with MG and 148 healthy controls were recruited. Using improved multiple ligase detection reaction technology, the polymorphisms of rs2893321 between groups and among MG subgroups have been compared. RESULTS: A significant differences between the MG group and the healthy control group was observed. Additionally, rs2893321 was found to be associated with gender and age in patients with MG. CONCLUSION: Genetic variations of rs2893321 in BAFF might be associated with susceptibility to MG in the Chinese Han population.
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spelling pubmed-68224192019-11-06 Associations of BAFF rs2893321 polymorphisms with myasthenia gravis susceptibility Deng, Hui Wang, Jianjian Kong, Xiaotong Zhang, Huixue Wang, Tianfeng Tian, Wenqi Yi, Tingting Wang, Lihua BMC Med Genet Research Article BACKGROUND: Myasthenia gravis (MG) is an autoimmune diseases characterized by fatigue and weakness of skeletal muscles. B-lymphocyte-activating factor (BAFF), an essential factor for B cell differentiation and development, is important in the progression of MG. The current study aimed to investigate the association between single nucleotide polymorphism rs2893321 in BAFF with MG susceptibility in Chinese Han population. METHODS: One hundred forty-nine patients with MG and 148 healthy controls were recruited. Using improved multiple ligase detection reaction technology, the polymorphisms of rs2893321 between groups and among MG subgroups have been compared. RESULTS: A significant differences between the MG group and the healthy control group was observed. Additionally, rs2893321 was found to be associated with gender and age in patients with MG. CONCLUSION: Genetic variations of rs2893321 in BAFF might be associated with susceptibility to MG in the Chinese Han population. BioMed Central 2019-10-30 /pmc/articles/PMC6822419/ /pubmed/31666013 http://dx.doi.org/10.1186/s12881-019-0906-8 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Deng, Hui
Wang, Jianjian
Kong, Xiaotong
Zhang, Huixue
Wang, Tianfeng
Tian, Wenqi
Yi, Tingting
Wang, Lihua
Associations of BAFF rs2893321 polymorphisms with myasthenia gravis susceptibility
title Associations of BAFF rs2893321 polymorphisms with myasthenia gravis susceptibility
title_full Associations of BAFF rs2893321 polymorphisms with myasthenia gravis susceptibility
title_fullStr Associations of BAFF rs2893321 polymorphisms with myasthenia gravis susceptibility
title_full_unstemmed Associations of BAFF rs2893321 polymorphisms with myasthenia gravis susceptibility
title_short Associations of BAFF rs2893321 polymorphisms with myasthenia gravis susceptibility
title_sort associations of baff rs2893321 polymorphisms with myasthenia gravis susceptibility
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822419/
https://www.ncbi.nlm.nih.gov/pubmed/31666013
http://dx.doi.org/10.1186/s12881-019-0906-8
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