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GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway

BACKGROUND: Glutathione S-transferase zeta 1 (GSTZ1) is the penultimate enzyme in phenylalanine/tyrosine catabolism. GSTZ1 is dysregulated in cancers; however, its role in tumorigenesis and progression of hepatocellular carcinoma (HCC) is largely unknown. We aimed to assess the role of GSTZ1 in HCC...

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Detalles Bibliográficos
Autores principales:	Li, Jingjing, Wang, Qiujie, Yang, Yi, Lei, Chong, Yang, Fan, Liang, Li, Chen, Chang, Xia, Jie, Wang, Kai, Tang, Ni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822483/ https://www.ncbi.nlm.nih.gov/pubmed/31666108 http://dx.doi.org/10.1186/s13046-019-1459-6

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