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Non-Invasive Imaging of Normalized Solid Stress in Cancers in Vivo
The solid stress (SSg) that develops inside a cancer is an important marker of cancer’s growth, invasion and metastasis. Currently, there are no non-invasive methods to image SSg inside tumors. In this paper, we develop a new, non-invasive and cost-effective imaging method to assess SSg inside tumor...
Formato: | Online Artículo Texto |
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Lenguaje: | English |
Publicado: |
IEEE
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822636/ https://www.ncbi.nlm.nih.gov/pubmed/32309062 http://dx.doi.org/10.1109/JTEHM.2019.2932059 |
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collection | PubMed |
description | The solid stress (SSg) that develops inside a cancer is an important marker of cancer’s growth, invasion and metastasis. Currently, there are no non-invasive methods to image SSg inside tumors. In this paper, we develop a new, non-invasive and cost-effective imaging method to assess SSg inside tumors that uses ultrasound poroelastography. Center to the proposed method is a novel analytical model, which demonstrates that SSg and the compression-induced stress (SSc) that generates inside the cancer in a poroelastography experiment have the same spatial distribution. To show the clinical feasibility of the proposed technique, we imaged and analyzed the normalized SSg inside treated and untreated human breast cancers in a small animal model. Given the clinical significance of assessing SSg in cancers and the advantages of the proposed ultrasonic methods, our technique could have a great impact on cancer diagnosis, prognosis and treatment methods. |
format | Online Article Text |
id | pubmed-6822636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | IEEE |
record_format | MEDLINE/PubMed |
spelling | pubmed-68226362020-04-17 Non-Invasive Imaging of Normalized Solid Stress in Cancers in Vivo IEEE J Transl Eng Health Med Article The solid stress (SSg) that develops inside a cancer is an important marker of cancer’s growth, invasion and metastasis. Currently, there are no non-invasive methods to image SSg inside tumors. In this paper, we develop a new, non-invasive and cost-effective imaging method to assess SSg inside tumors that uses ultrasound poroelastography. Center to the proposed method is a novel analytical model, which demonstrates that SSg and the compression-induced stress (SSc) that generates inside the cancer in a poroelastography experiment have the same spatial distribution. To show the clinical feasibility of the proposed technique, we imaged and analyzed the normalized SSg inside treated and untreated human breast cancers in a small animal model. Given the clinical significance of assessing SSg in cancers and the advantages of the proposed ultrasonic methods, our technique could have a great impact on cancer diagnosis, prognosis and treatment methods. IEEE 2019-09-13 /pmc/articles/PMC6822636/ /pubmed/32309062 http://dx.doi.org/10.1109/JTEHM.2019.2932059 Text en https://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Non-Invasive Imaging of Normalized Solid Stress in Cancers in Vivo |
title | Non-Invasive Imaging of Normalized Solid Stress in Cancers in Vivo |
title_full | Non-Invasive Imaging of Normalized Solid Stress in Cancers in Vivo |
title_fullStr | Non-Invasive Imaging of Normalized Solid Stress in Cancers in Vivo |
title_full_unstemmed | Non-Invasive Imaging of Normalized Solid Stress in Cancers in Vivo |
title_short | Non-Invasive Imaging of Normalized Solid Stress in Cancers in Vivo |
title_sort | non-invasive imaging of normalized solid stress in cancers in vivo |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822636/ https://www.ncbi.nlm.nih.gov/pubmed/32309062 http://dx.doi.org/10.1109/JTEHM.2019.2932059 |
work_keys_str_mv | AT noninvasiveimagingofnormalizedsolidstressincancersinvivo AT noninvasiveimagingofnormalizedsolidstressincancersinvivo AT noninvasiveimagingofnormalizedsolidstressincancersinvivo |