Cargando…

Mitochondrial dysfunctions in leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL)

Several inherited human diseases have been linked to mitochondrial aminoacyl-tRNA synthetases (mtARSs). Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) is a leukodystrophy caused by mutations in the DARS2 gene which encodes mitochondrial aspartyl-tRNA synt...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Tsu-Kung, Chang, Yung-Yee, Lin, Hung-Yu, Liou, Chia-Wei, Wang, Pei-Wen, Chuang, Jiin-Haur, Chen, Shang-Der, Chuang, Yao-Chung, Huang, Sheng-Teng, Hsu, Te-Yao, Peng, Cheng-Huei, Lan, Min-Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822708/ https://www.ncbi.nlm.nih.gov/pubmed/31671122 http://dx.doi.org/10.1371/journal.pone.0224173

Ejemplares similares

Perinatal Manifestations of DARS2-Associated Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL)
por: Ngo, Julie, et al.
Publicado: (2021)

Mitochondrial Transfer from Wharton's Jelly Mesenchymal Stem Cell to MERRF Cybrid Reduces Oxidative Stress and Improves Mitochondrial Bioenergetics
por: Chuang, Yao-Chung, et al.
Publicado: (2017)

Quality Matters? The Involvement of Mitochondrial Quality Control in Cardiovascular Disease
por: Lin, Kai-Lieh, et al.
Publicado: (2021)

The Creation of Cybrids Harboring Mitochondrial Haplogroups in the Taiwanese Population of Ethnic Chinese Background: An Extensive In Vitro Tool for the Study of Mitochondrial Genomic Variations
por: Lin, Tsu-Kung, et al.
Publicado: (2012)

When Friendship Turns Sour: Effective Communication Between Mitochondria and Intracellular Organelles in Parkinson's Disease
por: Lin, Tsu-Kung, et al.
Publicado: (2020)

Resveratrol Partially Prevents Rotenone-Induced Neurotoxicity in Dopaminergic SH-SY5Y Cells through Induction of Heme Oxygenase-1 Dependent Autophagy
por: Lin, Tsu-Kung, et al.
Publicado: (2014)

Mitochondrial Transfer of Wharton's Jelly Mesenchymal Stem Cells Eliminates Mutation Burden and Rescues Mitochondrial Bioenergetics in Rotenone-Stressed MELAS Fibroblasts
por: Lin, Tsu-Kung, et al.
Publicado: (2019)

The Leukodystrophies HBSL and LBSL—Correlates and Distinctions
por: Muthiah, Annapoorani, et al.
Publicado: (2021)

Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation: A Novel DARS2 Mutation and Intra‐Familial Heterogeneity
por: Li, Jeng‐Lin, et al.
Publicado: (2021)

Tanshinone IIA induces intrinsic apoptosis in osteosarcoma cells both in vivo and in vitro associated with mitochondrial dysfunction
por: Huang, Sheng-Teng, et al.
Publicado: (2017)

5-aza-2′-Deoxycytidine Induces a RIG-I-Related Innate Immune Response by Modulating Mitochondria Stress in Neuroblastoma
por: Lin, Hung-Yu, et al.
Publicado: (2020)

Phyllanthus urinaria Induces Apoptosis in Human Osteosarcoma 143B Cells via Activation of Fas/FasL- and Mitochondria-Mediated Pathways
por: Wu, Hsin-Yi, et al.
Publicado: (2012)

mtDNA as a Mediator for Expression of Hypoxia-Inducible Factor 1α and ROS in Hypoxic Neuroblastoma Cells
por: Kuo, Chung-Wen, et al.
Publicado: (2017)

Two Birds One Stone: The Neuroprotective Effect of Antidiabetic Agents on Parkinson Disease—Focus on Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors
por: Lin, Kai-Jung, et al.
Publicado: (2021)

A novel DARS2 mutation in a Japanese patient with leukoencephalopathy with brainstem and spinal cord involvement but no lactate elevation
por: Shimojima, Keiko, et al.
Publicado: (2017)

Ischemic Stroke Risk Associated with Mitochondrial Haplogroup F in the Asian Population
por: Tsai, Meng-Han, et al.
Publicado: (2020)

Mitochondrial DNA Coding and Control Region Variants as Genetic Risk Factors for Type 2 Diabetes
por: Liou, Chia-Wei, et al.
Publicado: (2012)

Glycolytic inhibitor 2-deoxyglucose simultaneously targets cancer and endothelial cells to suppress neuroblastoma growth in mice
por: Huang, Chao-Cheng, et al.
Publicado: (2015)

Wearable sensors detect impaired gait and coordination in LBSL during remote assessments
por: Smith Fine, Amena, et al.
Publicado: (2022)

The Causal Role of Mitochondrial Dynamics in Regulating Innate Immunity in Diabetes
por: Chang, Yen-Hsiang, et al.
Publicado: (2020)

Associations of Mitochondrial Haplogroups B4 and E with Biliary Atresia and Differential Susceptibility to Hydrophobic Bile Acid
por: Tiao, Mao-Meng, et al.
Publicado: (2013)

Leigh Syndrome Due to NDUFV1 Mutations Initially Presenting as LBSL
por: Borna, Nurun Nahar, et al.
Publicado: (2020)

Two Clinical Cases of LBSL: Diagnostic Problems and Possible Therapeutic Approaches
por: Bedova, Mariia A., et al.
Publicado: (2020)

Glucagon-Like Peptide-1 Receptor Agonist Ameliorates 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Neurotoxicity Through Enhancing Mitophagy Flux and Reducing α-Synuclein and Oxidative Stress
por: Lin, Tsu-Kung, et al.
Publicado: (2021)

The Overcrowded Crossroads: Mitochondria, Alpha-Synuclein, and the Endo-Lysosomal System Interaction in Parkinson’s Disease
por: Lin, Kai-Jung, et al.
Publicado: (2019)

Leukoencephalopathy hypomyelination with brainstem and spinal cord involvement and leg spasticity caused by DARS1 mutations
por: Zhu, Jingyi, et al.
Publicado: (2023)

Roles of Sestrin2 and Ribosomal Protein S6 in Transient Global Ischemia-Induced Hippocampal Neuronal Injury
por: Chuang, Yao-Chung, et al.
Publicado: (2015)

Peroxisome proliferator-activated receptor-gamma dependent pathway reduces the phosphorylation of dynamin-related protein 1 and ameliorates hippocampal injury induced by global ischemia in rats
por: Chuang, Yao-Chung, et al.
Publicado: (2016)

Intra-familial phenotypic heterogeneity in a Sudanese family with DARS2-related leukoencephalopathy, brainstem and spinal cord involvement and lactate elevation: a case report
por: Yahia, Ashraf, et al.
Publicado: (2018)

Roles of Oxidative Stress, Apoptosis, PGC-1α and Mitochondrial Biogenesis in Cerebral Ischemia
por: Chen, Shang-Der, et al.
Publicado: (2011)

Mitochondrial Dysfunction and Oxidative Stress Promote Apoptotic Cell Death in the Striatum via Cytochrome c/Caspase-3 Signaling Cascade Following Chronic Rotenone Intoxication in Rats
por: Lin, Tsu-Kung, et al.
Publicado: (2012)

The Causal Role of Mitochondrial Dynamics in Regulating Insulin Resistance in Diabetes: Link through Mitochondrial Reactive Oxygen Species
por: Lin, Hung-Yu, et al.
Publicado: (2018)

Seizure-Induced Oxidative Stress in Status Epilepticus: Is Antioxidant Beneficial?
por: Lin, Tsu-Kung, et al.
Publicado: (2020)

Macrophage Inflammatory Protein-1 Alpha, a Potential Biomarker for Predicting Left Atrial Remodeling in Patients With Atrial Fibrillation
por: Chen, Yung-Lung, et al.
Publicado: (2021)

KARS-related diseases: progressive leukoencephalopathy with brainstem and spinal cord calcifications as new phenotype and a review of literature
por: Ardissone, Anna, et al.
Publicado: (2018)

Brainstem phenotype of cathepsin A–related arteriopathy with strokes and leukoencephalopathy
por: Hwang, Yun Tae, et al.
Publicado: (2017)

Clinically Isolated Brainstem Progressive Multifocal Leukoencephalopathy: Diagnostic Challenges
por: Khan, Faisal, et al.
Publicado: (2022)

LBSL: Case Series and DARS2 Variant Analysis in Early Severe Forms With Unexpected Presentations
por: Stellingwerff, Menno D., et al.
Publicado: (2021)

A Study on MDA5 Signaling in Splenic B Cells from an Imiquimod-Induced Lupus Mouse Model with Proteomics
por: Su, Yu-Jih, et al.
Publicado: (2022)

Mitochondrial haplogroups have a better correlation to insulin requirement than nuclear genetic variants for type 2 diabetes mellitus in Taiwanese individuals
por: Shen, Feng‐Chih, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i2b20k272r6i5jnm8vr49kdhr5