BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss

Neurotrophins and their mimetics are potential treatments for hearing disorders because of their trophic effects on spiral ganglion neurons (SGNs) whose connections to hair cells may be compromised in many forms of hearing loss. Studies in noise or ototoxin-exposed animals have shown that local deli...

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Detalles Bibliográficos
Autores principales: Szobota, Stephanie, Mathur, Pranav D., Siegel, Sairey, Black, KristenAnn, Saragovi, H. Uri, Foster, Alan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822712/
https://www.ncbi.nlm.nih.gov/pubmed/31671109
http://dx.doi.org/10.1371/journal.pone.0224022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822712/
https://www.ncbi.nlm.nih.gov/pubmed/31671109
http://dx.doi.org/10.1371/journal.pone.0224022

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