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MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging

Mendelian randomization (MR) is an established approach to evaluate the effect of an exposure on an outcome. The gene-by-environment (GxE) study design can be used to determine whether the genetic instrument affects the outcome through pathways other than via the exposure of interest (horizontal ple...

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Detalles Bibliográficos
Autores principales:	Millard, Louise A. C., Munafò, Marcus R., Tilling, Kate, Wootton, Robyn E., Davey Smith, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822717/ https://www.ncbi.nlm.nih.gov/pubmed/31671092 http://dx.doi.org/10.1371/journal.pgen.1008353

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