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Thymoma-Induced Autoimmune Hepatitis: A Rare Paraneoplastic Syndrome

Thymomas are rare neoplasms of the thymus and are often associated with immune-mediated paraneoplastic syndromes, most commonly, myasthenia gravis. The same underlying mechanism can produce antibodies to other self-antigens in various organ systems. Autoimmune hepatitis is a rare complication of thy...

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Detalles Bibliográficos
Autores principales: Stilwell, Kendra T, Musick, Sierra R, Cebe, Katherine M, Morales-Cardona, Amilcar L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822890/
https://www.ncbi.nlm.nih.gov/pubmed/31700740
http://dx.doi.org/10.7759/cureus.5637
Descripción
Sumario:Thymomas are rare neoplasms of the thymus and are often associated with immune-mediated paraneoplastic syndromes, most commonly, myasthenia gravis. The same underlying mechanism can produce antibodies to other self-antigens in various organ systems. Autoimmune hepatitis is a rare complication of thymoma. We present a 35-year-old healthy male, initially thought to have drug-induced liver injury, who was subsequently diagnosed with thymoma-induced autoimmune hepatitis, a rare syndrome of which only two previous cases have been reported.