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Thymoma-Induced Autoimmune Hepatitis: A Rare Paraneoplastic Syndrome

Thymomas are rare neoplasms of the thymus and are often associated with immune-mediated paraneoplastic syndromes, most commonly, myasthenia gravis. The same underlying mechanism can produce antibodies to other self-antigens in various organ systems. Autoimmune hepatitis is a rare complication of thy...

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Autores principales: Stilwell, Kendra T, Musick, Sierra R, Cebe, Katherine M, Morales-Cardona, Amilcar L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822890/
https://www.ncbi.nlm.nih.gov/pubmed/31700740
http://dx.doi.org/10.7759/cureus.5637
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author Stilwell, Kendra T
Musick, Sierra R
Cebe, Katherine M
Morales-Cardona, Amilcar L
author_facet Stilwell, Kendra T
Musick, Sierra R
Cebe, Katherine M
Morales-Cardona, Amilcar L
author_sort Stilwell, Kendra T
collection PubMed
description Thymomas are rare neoplasms of the thymus and are often associated with immune-mediated paraneoplastic syndromes, most commonly, myasthenia gravis. The same underlying mechanism can produce antibodies to other self-antigens in various organ systems. Autoimmune hepatitis is a rare complication of thymoma. We present a 35-year-old healthy male, initially thought to have drug-induced liver injury, who was subsequently diagnosed with thymoma-induced autoimmune hepatitis, a rare syndrome of which only two previous cases have been reported.
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spelling pubmed-68228902019-11-07 Thymoma-Induced Autoimmune Hepatitis: A Rare Paraneoplastic Syndrome Stilwell, Kendra T Musick, Sierra R Cebe, Katherine M Morales-Cardona, Amilcar L Cureus Pathology Thymomas are rare neoplasms of the thymus and are often associated with immune-mediated paraneoplastic syndromes, most commonly, myasthenia gravis. The same underlying mechanism can produce antibodies to other self-antigens in various organ systems. Autoimmune hepatitis is a rare complication of thymoma. We present a 35-year-old healthy male, initially thought to have drug-induced liver injury, who was subsequently diagnosed with thymoma-induced autoimmune hepatitis, a rare syndrome of which only two previous cases have been reported. Cureus 2019-09-12 /pmc/articles/PMC6822890/ /pubmed/31700740 http://dx.doi.org/10.7759/cureus.5637 Text en Copyright © 2019, Stilwell et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Stilwell, Kendra T
Musick, Sierra R
Cebe, Katherine M
Morales-Cardona, Amilcar L
Thymoma-Induced Autoimmune Hepatitis: A Rare Paraneoplastic Syndrome
title Thymoma-Induced Autoimmune Hepatitis: A Rare Paraneoplastic Syndrome
title_full Thymoma-Induced Autoimmune Hepatitis: A Rare Paraneoplastic Syndrome
title_fullStr Thymoma-Induced Autoimmune Hepatitis: A Rare Paraneoplastic Syndrome
title_full_unstemmed Thymoma-Induced Autoimmune Hepatitis: A Rare Paraneoplastic Syndrome
title_short Thymoma-Induced Autoimmune Hepatitis: A Rare Paraneoplastic Syndrome
title_sort thymoma-induced autoimmune hepatitis: a rare paraneoplastic syndrome
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822890/
https://www.ncbi.nlm.nih.gov/pubmed/31700740
http://dx.doi.org/10.7759/cureus.5637
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