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Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina)
Microbial translocation is a cause of systemic immune activation in HIV/SIV infection. In the present study, we found a lower CD8(+) T cell activation level in Macaca leonina (northern pig-tailed macaques, NPMs) than in Macaca mulatta (Chinese rhesus macaques, ChRMs) during SIVmac239 infection. Furt...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Science Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822932/ https://www.ncbi.nlm.nih.gov/pubmed/31033262 http://dx.doi.org/10.24272/j.issn.2095-8137.2019.047 |
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author | Zhang, Ming-Xu Song, Tian-Zhang Zheng, Hong-Yi Wang, Xue-Hui Lu, Ying Zhang, Han-Dan Li, Ting Pang, Wei Zheng, Yong-Tang |
author_facet | Zhang, Ming-Xu Song, Tian-Zhang Zheng, Hong-Yi Wang, Xue-Hui Lu, Ying Zhang, Han-Dan Li, Ting Pang, Wei Zheng, Yong-Tang |
author_sort | Zhang, Ming-Xu |
collection | PubMed |
description | Microbial translocation is a cause of systemic immune activation in HIV/SIV infection. In the present study, we found a lower CD8(+) T cell activation level in Macaca leonina (northern pig-tailed macaques, NPMs) than in Macaca mulatta (Chinese rhesus macaques, ChRMs) during SIVmac239 infection. Furthermore, the levels of plasma LPS-binding protein and soluble CD14 in NPMs were lower than those in ChRMs. Compared with ChRMs, SIV-infected NPMs had lower Chiu scores, representing relatively normal intestinal mucosa. In addition, no obvious damage to the ileum or colon epithelial barrier was observed in either infected or uninfected NPMs, which differed to that found in ChRMs. Furthermore, no significant microbial translocation ( Escherichia coli) was detected in the colon or ileum of infected or uninfected NPMs, which again differed to that observed in ChRMs. In conclusion, NPMs retained superior intestinal integrity and limited microbial translocation during SIV infection, which may contribute to their lower immune activation compared with ChRMs. |
format | Online Article Text |
id | pubmed-6822932 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Science Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-68229322020-03-03 Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina) Zhang, Ming-Xu Song, Tian-Zhang Zheng, Hong-Yi Wang, Xue-Hui Lu, Ying Zhang, Han-Dan Li, Ting Pang, Wei Zheng, Yong-Tang Zool Res Articles Microbial translocation is a cause of systemic immune activation in HIV/SIV infection. In the present study, we found a lower CD8(+) T cell activation level in Macaca leonina (northern pig-tailed macaques, NPMs) than in Macaca mulatta (Chinese rhesus macaques, ChRMs) during SIVmac239 infection. Furthermore, the levels of plasma LPS-binding protein and soluble CD14 in NPMs were lower than those in ChRMs. Compared with ChRMs, SIV-infected NPMs had lower Chiu scores, representing relatively normal intestinal mucosa. In addition, no obvious damage to the ileum or colon epithelial barrier was observed in either infected or uninfected NPMs, which differed to that found in ChRMs. Furthermore, no significant microbial translocation ( Escherichia coli) was detected in the colon or ileum of infected or uninfected NPMs, which again differed to that observed in ChRMs. In conclusion, NPMs retained superior intestinal integrity and limited microbial translocation during SIV infection, which may contribute to their lower immune activation compared with ChRMs. Science Press 2019-04-10 2019-11-18 /pmc/articles/PMC6822932/ /pubmed/31033262 http://dx.doi.org/10.24272/j.issn.2095-8137.2019.047 Text en Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Zhang, Ming-Xu Song, Tian-Zhang Zheng, Hong-Yi Wang, Xue-Hui Lu, Ying Zhang, Han-Dan Li, Ting Pang, Wei Zheng, Yong-Tang Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina) |
title | Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina) |
title_full | Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina) |
title_fullStr | Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina) |
title_full_unstemmed | Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina) |
title_short | Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina) |
title_sort | superior intestinal integrity and limited microbial translocation are associated with lower immune activation in sivmac239-infected northern pig-tailed macaques (macaca leonina) |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822932/ https://www.ncbi.nlm.nih.gov/pubmed/31033262 http://dx.doi.org/10.24272/j.issn.2095-8137.2019.047 |
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