Eliminating Meningococcal Epidemics From the African Meningitis Belt: The Case for Advanced Prevention and Control Using Next-Generation Meningococcal Conjugate Vaccines

The introduction and rollout of a meningococcal serogroup A conjugate vaccine, MenAfriVac, in the African meningitis belt has eliminated serogroup A meningococcal infections for >300 million Africans. However, serogroup C, W, and X meningococci continue to circulate and have been responsible for...

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Autores principales: Alderson, Mark R, LaForce, F Marc, Sobanjo-ter Meulen, Ajoke, Hwang, Angela, Preziosi, Marie-Pierre, Klugman, Keith P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Supplement Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822963/
https://www.ncbi.nlm.nih.gov/pubmed/31671447
http://dx.doi.org/10.1093/infdis/jiz297
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author Alderson, Mark R
LaForce, F Marc
Sobanjo-ter Meulen, Ajoke
Hwang, Angela
Preziosi, Marie-Pierre
Klugman, Keith P
author_facet Alderson, Mark R
LaForce, F Marc
Sobanjo-ter Meulen, Ajoke
Hwang, Angela
Preziosi, Marie-Pierre
Klugman, Keith P
author_sort Alderson, Mark R
collection PubMed
description The introduction and rollout of a meningococcal serogroup A conjugate vaccine, MenAfriVac, in the African meningitis belt has eliminated serogroup A meningococcal infections for >300 million Africans. However, serogroup C, W, and X meningococci continue to circulate and have been responsible for focal epidemics in meningitis belt countries. Affordable multivalent meningococcal conjugate vaccines are being developed to prevent these non-A epidemics. This article describes the current epidemiologic situation and status of vaccine development and highlights questions to be addressed to most efficiently use these new vaccines.
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spelling pubmed-68229632019-11-06 Eliminating Meningococcal Epidemics From the African Meningitis Belt: The Case for Advanced Prevention and Control Using Next-Generation Meningococcal Conjugate Vaccines Alderson, Mark R LaForce, F Marc Sobanjo-ter Meulen, Ajoke Hwang, Angela Preziosi, Marie-Pierre Klugman, Keith P J Infect Dis Supplement Articles The introduction and rollout of a meningococcal serogroup A conjugate vaccine, MenAfriVac, in the African meningitis belt has eliminated serogroup A meningococcal infections for >300 million Africans. However, serogroup C, W, and X meningococci continue to circulate and have been responsible for focal epidemics in meningitis belt countries. Affordable multivalent meningococcal conjugate vaccines are being developed to prevent these non-A epidemics. This article describes the current epidemiologic situation and status of vaccine development and highlights questions to be addressed to most efficiently use these new vaccines. Oxford University Press 2019-12-01 2019-10-31 /pmc/articles/PMC6822963/ /pubmed/31671447 http://dx.doi.org/10.1093/infdis/jiz297 Text en © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Supplement Articles
Alderson, Mark R
LaForce, F Marc
Sobanjo-ter Meulen, Ajoke
Hwang, Angela
Preziosi, Marie-Pierre
Klugman, Keith P
Eliminating Meningococcal Epidemics From the African Meningitis Belt: The Case for Advanced Prevention and Control Using Next-Generation Meningococcal Conjugate Vaccines
title Eliminating Meningococcal Epidemics From the African Meningitis Belt: The Case for Advanced Prevention and Control Using Next-Generation Meningococcal Conjugate Vaccines
title_full Eliminating Meningococcal Epidemics From the African Meningitis Belt: The Case for Advanced Prevention and Control Using Next-Generation Meningococcal Conjugate Vaccines
title_fullStr Eliminating Meningococcal Epidemics From the African Meningitis Belt: The Case for Advanced Prevention and Control Using Next-Generation Meningococcal Conjugate Vaccines
title_full_unstemmed Eliminating Meningococcal Epidemics From the African Meningitis Belt: The Case for Advanced Prevention and Control Using Next-Generation Meningococcal Conjugate Vaccines
title_short Eliminating Meningococcal Epidemics From the African Meningitis Belt: The Case for Advanced Prevention and Control Using Next-Generation Meningococcal Conjugate Vaccines
title_sort eliminating meningococcal epidemics from the african meningitis belt: the case for advanced prevention and control using next-generation meningococcal conjugate vaccines
topic Supplement Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822963/
https://www.ncbi.nlm.nih.gov/pubmed/31671447
http://dx.doi.org/10.1093/infdis/jiz297
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