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Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training

Hypotheses of striatal orchestration of behavior ascribe distinct functions to striatal subregions, with the dorsolateral striatum (DLS) especially implicated in habitual and skilled performance. Thus neural activity patterns recorded from the DLS, but not the dorsomedial striatum (DMS), should be c...

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Autores principales: Vandaele, Youna, Mahajan, Nagaraj R, Ottenheimer, David J, Richard, Jocelyn M, Mysore, Shreesh P, Janak, Patricia H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822989/
https://www.ncbi.nlm.nih.gov/pubmed/31621583
http://dx.doi.org/10.7554/eLife.49536
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author Vandaele, Youna
Mahajan, Nagaraj R
Ottenheimer, David J
Richard, Jocelyn M
Mysore, Shreesh P
Janak, Patricia H
author_facet Vandaele, Youna
Mahajan, Nagaraj R
Ottenheimer, David J
Richard, Jocelyn M
Mysore, Shreesh P
Janak, Patricia H
author_sort Vandaele, Youna
collection PubMed
description Hypotheses of striatal orchestration of behavior ascribe distinct functions to striatal subregions, with the dorsolateral striatum (DLS) especially implicated in habitual and skilled performance. Thus neural activity patterns recorded from the DLS, but not the dorsomedial striatum (DMS), should be correlated with habitual and automatized performance. Here, we recorded DMS and DLS neural activity in rats during training in a task promoting habitual lever pressing. Despite improving performance across sessions, clear changes in corresponding neural activity patterns were not evident in DMS or DLS during early training. Although DMS and DLS activity patterns were distinct during early training, their activity was similar following extended training. Finally, performance after extended training was not associated with DMS disengagement, as would be predicted from prior work. These results suggest that behavioral sequences may continue to engage both striatal regions long after initial acquisition, when skilled performance is consolidated.
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spelling pubmed-68229892019-11-04 Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training Vandaele, Youna Mahajan, Nagaraj R Ottenheimer, David J Richard, Jocelyn M Mysore, Shreesh P Janak, Patricia H eLife Neuroscience Hypotheses of striatal orchestration of behavior ascribe distinct functions to striatal subregions, with the dorsolateral striatum (DLS) especially implicated in habitual and skilled performance. Thus neural activity patterns recorded from the DLS, but not the dorsomedial striatum (DMS), should be correlated with habitual and automatized performance. Here, we recorded DMS and DLS neural activity in rats during training in a task promoting habitual lever pressing. Despite improving performance across sessions, clear changes in corresponding neural activity patterns were not evident in DMS or DLS during early training. Although DMS and DLS activity patterns were distinct during early training, their activity was similar following extended training. Finally, performance after extended training was not associated with DMS disengagement, as would be predicted from prior work. These results suggest that behavioral sequences may continue to engage both striatal regions long after initial acquisition, when skilled performance is consolidated. eLife Sciences Publications, Ltd 2019-10-17 /pmc/articles/PMC6822989/ /pubmed/31621583 http://dx.doi.org/10.7554/eLife.49536 Text en © 2019, Vandaele et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Vandaele, Youna
Mahajan, Nagaraj R
Ottenheimer, David J
Richard, Jocelyn M
Mysore, Shreesh P
Janak, Patricia H
Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training
title Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training
title_full Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training
title_fullStr Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training
title_full_unstemmed Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training
title_short Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training
title_sort distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822989/
https://www.ncbi.nlm.nih.gov/pubmed/31621583
http://dx.doi.org/10.7554/eLife.49536
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