Common brain disorders are associated with heritable patterns of apparent aging of the brain

Common risk factors for psychiatric and other brain disorders likely converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural magnetic resonance imaging data from 45,615 individuals aged 3 to 96 years, we demonstrate di...

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Detalles Bibliográficos
Autores principales: Kaufmann, Tobias, van der Meer, Dennis, Doan, Nhat Trung, Schwarz, Emanuel, Lund, Martina J., Agartz, Ingrid, Alnæs, Dag, Barch, Deanna M., Baur-Streubel, Ramona, Bertolino, Alessandro, Bettella, Francesco, Beyer, Mona K., Bøen, Erlend, Borgwardt, Stefan, Brandt, Christine L., Buitelaar, Jan, Celius, Elisabeth G., Cervenka, Simon, Conzelmann, Annette, Córdova-Palomera, Aldo, Dale, Anders M., de Quervain, Dominique J. F., Carlo, PasqualeDi, Djurovic, Srdjan, Dørum, Erlend S., Eisenacher, Sarah, Elvsåshagen, Torbjørn, Espeseth, Thomas, Fatouros-Bergman, Helena, Flyckt, Lena, Franke, Barbara, Frei, Oleksandr, Haatveit, Beathe, Håberg, Asta K., Harbo, Hanne F., Hartman, Catharina A., Heslenfeld, Dirk, Hoekstra, Pieter J., Høgestøl, Einar A., Jernigan, Terry L., Jonassen, Rune, Jönsson, Erik G., Kirsch, Peter, Kłoszewska, Iwona, Kolskår, Knut K., Landrø, Nils Inge, Hellard, StephanieLe, Lesch, Klaus-Peter, Lovestone, Simon, Lundervold, Arvid, Lundervold, Astri J., Maglanoc, Luigi A., Malt, Ulrik F., Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Norbom, Linn B., Nordvik, Jan Egil, Nyberg, Lars, Oosterlaan, Jaap, Papalino, Marco, Papassotiropoulos, Andreas, Pauli, Paul, Pergola, Giulio, Persson, Karin, Richard, Geneviève, Rokicki, Jaroslav, Sanders, Anne-Marthe, Selbæk, Geir, Shadrin, Alexey A., Smeland, Olav B., Soininen, Hilkka, Sowa, Piotr, Steen, Vidar M., Tsolaki, Magda, Ulrichsen, Kristine M., Vellas, Bruno, Wang, Lei, Westman, Eric, Ziegler, Georg C., Zink, Mathias, Andreassen, Ole A., Westlye, Lars T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823048/
https://www.ncbi.nlm.nih.gov/pubmed/31551603
http://dx.doi.org/10.1038/s41593-019-0471-7
Descripción
Sumario:Common risk factors for psychiatric and other brain disorders likely converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural magnetic resonance imaging data from 45,615 individuals aged 3 to 96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

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