Cargando…
Common brain disorders are associated with heritable patterns of apparent aging of the brain
Common risk factors for psychiatric and other brain disorders likely converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural magnetic resonance imaging data from 45,615 individuals aged 3 to 96 years, we demonstrate di...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823048/ https://www.ncbi.nlm.nih.gov/pubmed/31551603 http://dx.doi.org/10.1038/s41593-019-0471-7 |
| _version_ | 1783464464589258752 |
|---|---|
| author | Kaufmann, Tobias van der Meer, Dennis Doan, Nhat Trung Schwarz, Emanuel Lund, Martina J. Agartz, Ingrid Alnæs, Dag Barch, Deanna M. Baur-Streubel, Ramona Bertolino, Alessandro Bettella, Francesco Beyer, Mona K. Bøen, Erlend Borgwardt, Stefan Brandt, Christine L. Buitelaar, Jan Celius, Elisabeth G. Cervenka, Simon Conzelmann, Annette Córdova-Palomera, Aldo Dale, Anders M. de Quervain, Dominique J. F. Carlo, PasqualeDi Djurovic, Srdjan Dørum, Erlend S. Eisenacher, Sarah Elvsåshagen, Torbjørn Espeseth, Thomas Fatouros-Bergman, Helena Flyckt, Lena Franke, Barbara Frei, Oleksandr Haatveit, Beathe Håberg, Asta K. Harbo, Hanne F. Hartman, Catharina A. Heslenfeld, Dirk Hoekstra, Pieter J. Høgestøl, Einar A. Jernigan, Terry L. Jonassen, Rune Jönsson, Erik G. Kirsch, Peter Kłoszewska, Iwona Kolskår, Knut K. Landrø, Nils Inge Hellard, StephanieLe Lesch, Klaus-Peter Lovestone, Simon Lundervold, Arvid Lundervold, Astri J. Maglanoc, Luigi A. Malt, Ulrik F. Mecocci, Patrizia Melle, Ingrid Meyer-Lindenberg, Andreas Moberget, Torgeir Norbom, Linn B. Nordvik, Jan Egil Nyberg, Lars Oosterlaan, Jaap Papalino, Marco Papassotiropoulos, Andreas Pauli, Paul Pergola, Giulio Persson, Karin Richard, Geneviève Rokicki, Jaroslav Sanders, Anne-Marthe Selbæk, Geir Shadrin, Alexey A. Smeland, Olav B. Soininen, Hilkka Sowa, Piotr Steen, Vidar M. Tsolaki, Magda Ulrichsen, Kristine M. Vellas, Bruno Wang, Lei Westman, Eric Ziegler, Georg C. Zink, Mathias Andreassen, Ole A. Westlye, Lars T. |
| author_facet | Kaufmann, Tobias van der Meer, Dennis Doan, Nhat Trung Schwarz, Emanuel Lund, Martina J. Agartz, Ingrid Alnæs, Dag Barch, Deanna M. Baur-Streubel, Ramona Bertolino, Alessandro Bettella, Francesco Beyer, Mona K. Bøen, Erlend Borgwardt, Stefan Brandt, Christine L. Buitelaar, Jan Celius, Elisabeth G. Cervenka, Simon Conzelmann, Annette Córdova-Palomera, Aldo Dale, Anders M. de Quervain, Dominique J. F. Carlo, PasqualeDi Djurovic, Srdjan Dørum, Erlend S. Eisenacher, Sarah Elvsåshagen, Torbjørn Espeseth, Thomas Fatouros-Bergman, Helena Flyckt, Lena Franke, Barbara Frei, Oleksandr Haatveit, Beathe Håberg, Asta K. Harbo, Hanne F. Hartman, Catharina A. Heslenfeld, Dirk Hoekstra, Pieter J. Høgestøl, Einar A. Jernigan, Terry L. Jonassen, Rune Jönsson, Erik G. Kirsch, Peter Kłoszewska, Iwona Kolskår, Knut K. Landrø, Nils Inge Hellard, StephanieLe Lesch, Klaus-Peter Lovestone, Simon Lundervold, Arvid Lundervold, Astri J. Maglanoc, Luigi A. Malt, Ulrik F. Mecocci, Patrizia Melle, Ingrid Meyer-Lindenberg, Andreas Moberget, Torgeir Norbom, Linn B. Nordvik, Jan Egil Nyberg, Lars Oosterlaan, Jaap Papalino, Marco Papassotiropoulos, Andreas Pauli, Paul Pergola, Giulio Persson, Karin Richard, Geneviève Rokicki, Jaroslav Sanders, Anne-Marthe Selbæk, Geir Shadrin, Alexey A. Smeland, Olav B. Soininen, Hilkka Sowa, Piotr Steen, Vidar M. Tsolaki, Magda Ulrichsen, Kristine M. Vellas, Bruno Wang, Lei Westman, Eric Ziegler, Georg C. Zink, Mathias Andreassen, Ole A. Westlye, Lars T. |
| author_sort | Kaufmann, Tobias |
| collection | PubMed |
| description | Common risk factors for psychiatric and other brain disorders likely converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural magnetic resonance imaging data from 45,615 individuals aged 3 to 96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders. |
| format | Online Article Text |
| id | pubmed-6823048 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-68230482020-03-24 Common brain disorders are associated with heritable patterns of apparent aging of the brain Kaufmann, Tobias van der Meer, Dennis Doan, Nhat Trung Schwarz, Emanuel Lund, Martina J. Agartz, Ingrid Alnæs, Dag Barch, Deanna M. Baur-Streubel, Ramona Bertolino, Alessandro Bettella, Francesco Beyer, Mona K. Bøen, Erlend Borgwardt, Stefan Brandt, Christine L. Buitelaar, Jan Celius, Elisabeth G. Cervenka, Simon Conzelmann, Annette Córdova-Palomera, Aldo Dale, Anders M. de Quervain, Dominique J. F. Carlo, PasqualeDi Djurovic, Srdjan Dørum, Erlend S. Eisenacher, Sarah Elvsåshagen, Torbjørn Espeseth, Thomas Fatouros-Bergman, Helena Flyckt, Lena Franke, Barbara Frei, Oleksandr Haatveit, Beathe Håberg, Asta K. Harbo, Hanne F. Hartman, Catharina A. Heslenfeld, Dirk Hoekstra, Pieter J. Høgestøl, Einar A. Jernigan, Terry L. Jonassen, Rune Jönsson, Erik G. Kirsch, Peter Kłoszewska, Iwona Kolskår, Knut K. Landrø, Nils Inge Hellard, StephanieLe Lesch, Klaus-Peter Lovestone, Simon Lundervold, Arvid Lundervold, Astri J. Maglanoc, Luigi A. Malt, Ulrik F. Mecocci, Patrizia Melle, Ingrid Meyer-Lindenberg, Andreas Moberget, Torgeir Norbom, Linn B. Nordvik, Jan Egil Nyberg, Lars Oosterlaan, Jaap Papalino, Marco Papassotiropoulos, Andreas Pauli, Paul Pergola, Giulio Persson, Karin Richard, Geneviève Rokicki, Jaroslav Sanders, Anne-Marthe Selbæk, Geir Shadrin, Alexey A. Smeland, Olav B. Soininen, Hilkka Sowa, Piotr Steen, Vidar M. Tsolaki, Magda Ulrichsen, Kristine M. Vellas, Bruno Wang, Lei Westman, Eric Ziegler, Georg C. Zink, Mathias Andreassen, Ole A. Westlye, Lars T. Nat Neurosci Article Common risk factors for psychiatric and other brain disorders likely converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural magnetic resonance imaging data from 45,615 individuals aged 3 to 96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders. 2019-10-01 2019-09-24 /pmc/articles/PMC6823048/ /pubmed/31551603 http://dx.doi.org/10.1038/s41593-019-0471-7 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Kaufmann, Tobias van der Meer, Dennis Doan, Nhat Trung Schwarz, Emanuel Lund, Martina J. Agartz, Ingrid Alnæs, Dag Barch, Deanna M. Baur-Streubel, Ramona Bertolino, Alessandro Bettella, Francesco Beyer, Mona K. Bøen, Erlend Borgwardt, Stefan Brandt, Christine L. Buitelaar, Jan Celius, Elisabeth G. Cervenka, Simon Conzelmann, Annette Córdova-Palomera, Aldo Dale, Anders M. de Quervain, Dominique J. F. Carlo, PasqualeDi Djurovic, Srdjan Dørum, Erlend S. Eisenacher, Sarah Elvsåshagen, Torbjørn Espeseth, Thomas Fatouros-Bergman, Helena Flyckt, Lena Franke, Barbara Frei, Oleksandr Haatveit, Beathe Håberg, Asta K. Harbo, Hanne F. Hartman, Catharina A. Heslenfeld, Dirk Hoekstra, Pieter J. Høgestøl, Einar A. Jernigan, Terry L. Jonassen, Rune Jönsson, Erik G. Kirsch, Peter Kłoszewska, Iwona Kolskår, Knut K. Landrø, Nils Inge Hellard, StephanieLe Lesch, Klaus-Peter Lovestone, Simon Lundervold, Arvid Lundervold, Astri J. Maglanoc, Luigi A. Malt, Ulrik F. Mecocci, Patrizia Melle, Ingrid Meyer-Lindenberg, Andreas Moberget, Torgeir Norbom, Linn B. Nordvik, Jan Egil Nyberg, Lars Oosterlaan, Jaap Papalino, Marco Papassotiropoulos, Andreas Pauli, Paul Pergola, Giulio Persson, Karin Richard, Geneviève Rokicki, Jaroslav Sanders, Anne-Marthe Selbæk, Geir Shadrin, Alexey A. Smeland, Olav B. Soininen, Hilkka Sowa, Piotr Steen, Vidar M. Tsolaki, Magda Ulrichsen, Kristine M. Vellas, Bruno Wang, Lei Westman, Eric Ziegler, Georg C. Zink, Mathias Andreassen, Ole A. Westlye, Lars T. Common brain disorders are associated with heritable patterns of apparent aging of the brain |
| title | Common brain disorders are associated with heritable patterns of apparent aging of the brain |
| title_full | Common brain disorders are associated with heritable patterns of apparent aging of the brain |
| title_fullStr | Common brain disorders are associated with heritable patterns of apparent aging of the brain |
| title_full_unstemmed | Common brain disorders are associated with heritable patterns of apparent aging of the brain |
| title_short | Common brain disorders are associated with heritable patterns of apparent aging of the brain |
| title_sort | common brain disorders are associated with heritable patterns of apparent aging of the brain |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823048/ https://www.ncbi.nlm.nih.gov/pubmed/31551603 http://dx.doi.org/10.1038/s41593-019-0471-7 |
| work_keys_str_mv | AT kaufmanntobias commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT vandermeerdennis commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT doannhattrung commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT schwarzemanuel commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT lundmartinaj commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT agartzingrid commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT alnæsdag commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT barchdeannam commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT baurstreubelramona commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT bertolinoalessandro commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT bettellafrancesco commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT beyermonak commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT bøenerlend commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT borgwardtstefan commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT brandtchristinel commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT buitelaarjan commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT celiuselisabethg commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT cervenkasimon commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT conzelmannannette commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT cordovapalomeraaldo commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT daleandersm commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT dequervaindominiquejf commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT carlopasqualedi commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT djurovicsrdjan commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT dørumerlends commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT eisenachersarah commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT elvsashagentorbjørn commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT espeseththomas commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT fatourosbergmanhelena commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT flycktlena commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT frankebarbara commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT freioleksandr commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT haatveitbeathe commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT habergastak commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT harbohannef commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT hartmancatharinaa commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT heslenfelddirk commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT hoekstrapieterj commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT høgestøleinara commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT jerniganterryl commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT jonassenrune commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT jonssonerikg commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT kirschpeter commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT kłoszewskaiwona commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT kolskarknutk commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT landrønilsinge commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT hellardstephaniele commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT leschklauspeter commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT lovestonesimon commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT lundervoldarvid commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT lundervoldastrij commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT maglanocluigia commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT maltulrikf commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT mecoccipatrizia commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT melleingrid commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT meyerlindenbergandreas commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT mobergettorgeir commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT norbomlinnb commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT nordvikjanegil commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT nyberglars commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT oosterlaanjaap commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT papalinomarco commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT papassotiropoulosandreas commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT paulipaul commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT pergolagiulio commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT perssonkarin commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT richardgenevieve commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT rokickijaroslav commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT sandersannemarthe commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT selbækgeir commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT shadrinalexeya commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT smelandolavb commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT soininenhilkka commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT sowapiotr commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT steenvidarm commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT tsolakimagda commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT ulrichsenkristinem commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT vellasbruno commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT wanglei commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT westmaneric commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT zieglergeorgc commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT zinkmathias commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT andreassenolea commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain AT westlyelarst commonbraindisordersareassociatedwithheritablepatternsofapparentagingofthebrain |