Stem Cells in Pituitary Tumors: Experimental Evidence Supporting Their Existence and Their Role in Tumor Clinical Behavior

Although generally benign, pituitary tumors frequently show local invasiveness and resistance to pharmacological therapy. After the demonstration of the existence of pituitary gland stem cells, over the past decade, the presence of a stem cell subpopulation in pituitary tumors has been investigated,...

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Autores principales: Mantovani, Giovanna, Giardino, Elena, Treppiedi, Donatella, Catalano, Rosa, Mangili, Federica, Spada, Anna, Arosio, Maura, Peverelli, Erika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823178/
https://www.ncbi.nlm.nih.gov/pubmed/31708878
http://dx.doi.org/10.3389/fendo.2019.00745
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author Mantovani, Giovanna
Giardino, Elena
Treppiedi, Donatella
Catalano, Rosa
Mangili, Federica
Spada, Anna
Arosio, Maura
Peverelli, Erika
author_facet Mantovani, Giovanna
Giardino, Elena
Treppiedi, Donatella
Catalano, Rosa
Mangili, Federica
Spada, Anna
Arosio, Maura
Peverelli, Erika
author_sort Mantovani, Giovanna
collection PubMed
description Although generally benign, pituitary tumors frequently show local invasiveness and resistance to pharmacological therapy. After the demonstration of the existence of pituitary gland stem cells, over the past decade, the presence of a stem cell subpopulation in pituitary tumors has been investigated, analogous to the cancer stem cell model developed for malignant tumors. This review recapitulates the experimental evidence supporting the existence of a population of stem-like cells in pituitary tumors, focusing on their potential role in tumor initiation, progression, recurrence and resistance to pharmacological therapy.
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spelling pubmed-68231782019-11-08 Stem Cells in Pituitary Tumors: Experimental Evidence Supporting Their Existence and Their Role in Tumor Clinical Behavior Mantovani, Giovanna Giardino, Elena Treppiedi, Donatella Catalano, Rosa Mangili, Federica Spada, Anna Arosio, Maura Peverelli, Erika Front Endocrinol (Lausanne) Endocrinology Although generally benign, pituitary tumors frequently show local invasiveness and resistance to pharmacological therapy. After the demonstration of the existence of pituitary gland stem cells, over the past decade, the presence of a stem cell subpopulation in pituitary tumors has been investigated, analogous to the cancer stem cell model developed for malignant tumors. This review recapitulates the experimental evidence supporting the existence of a population of stem-like cells in pituitary tumors, focusing on their potential role in tumor initiation, progression, recurrence and resistance to pharmacological therapy. Frontiers Media S.A. 2019-10-25 /pmc/articles/PMC6823178/ /pubmed/31708878 http://dx.doi.org/10.3389/fendo.2019.00745 Text en Copyright © 2019 Mantovani, Giardino, Treppiedi, Catalano, Mangili, Spada, Arosio and Peverelli. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Mantovani, Giovanna
Giardino, Elena
Treppiedi, Donatella
Catalano, Rosa
Mangili, Federica
Spada, Anna
Arosio, Maura
Peverelli, Erika
Stem Cells in Pituitary Tumors: Experimental Evidence Supporting Their Existence and Their Role in Tumor Clinical Behavior
title Stem Cells in Pituitary Tumors: Experimental Evidence Supporting Their Existence and Their Role in Tumor Clinical Behavior
title_full Stem Cells in Pituitary Tumors: Experimental Evidence Supporting Their Existence and Their Role in Tumor Clinical Behavior
title_fullStr Stem Cells in Pituitary Tumors: Experimental Evidence Supporting Their Existence and Their Role in Tumor Clinical Behavior
title_full_unstemmed Stem Cells in Pituitary Tumors: Experimental Evidence Supporting Their Existence and Their Role in Tumor Clinical Behavior
title_short Stem Cells in Pituitary Tumors: Experimental Evidence Supporting Their Existence and Their Role in Tumor Clinical Behavior
title_sort stem cells in pituitary tumors: experimental evidence supporting their existence and their role in tumor clinical behavior
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823178/
https://www.ncbi.nlm.nih.gov/pubmed/31708878
http://dx.doi.org/10.3389/fendo.2019.00745
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