S. cerevisiae Srs2 helicase ensures normal recombination intermediate metabolism during meiosis and prevents accumulation of Rad51 aggregates

We investigated the meiotic role of Srs2, a multi-functional DNA helicase/translocase that destabilises Rad51-DNA filaments and is thought to regulate strand invasion and prevent hyper-recombination during the mitotic cell cycle. We find that Srs2 activity is required for normal meiotic progression...

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Detalles Bibliográficos
Autores principales: Hunt, Laura J., Ahmed, Emad A., Kaur, Hardeep, Ahuja, Jasvinder S., Hulme, Lydia, Chou, Ta-Chung, Lichten, Michael, Goldman, Alastair S. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823294/
https://www.ncbi.nlm.nih.gov/pubmed/31069484
http://dx.doi.org/10.1007/s00412-019-00705-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823294/
https://www.ncbi.nlm.nih.gov/pubmed/31069484
http://dx.doi.org/10.1007/s00412-019-00705-9

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