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The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro

Exposure to aristolochic acid (AA) is associated with human nephropathy and urothelial cancer. The tumour suppressor TP53 is a critical gene in carcinogenesis and frequently mutated in AA-induced urothelial tumours. We investigated the impact of p53 on AAI-induced nephrotoxicity and DNA damage in vi...

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Detalles Bibliográficos
Autores principales:	Sborchia, Mateja, De Prez, Eric G., Antoine, Marie-Hélène, Bienfait, Lucie, Indra, Radek, Valbuena, Gabriel, Phillips, David H., Nortier, Joëlle L., Stiborová, Marie, Keun, Hector C., Arlt, Volker M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2019
Materias:	Genotoxicity and Carcinogenicity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823306/ https://www.ncbi.nlm.nih.gov/pubmed/31602497 http://dx.doi.org/10.1007/s00204-019-02578-4

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