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C9orf72-generated poly-GR and poly-PR do not directly interfere with nucleocytoplasmic transport

Repeat expansions in the C9orf72 gene cause amyotrophic lateral sclerosis and frontotemporal dementia characterized by dipeptide-repeat protein (DPR) inclusions. The toxicity associated with two of these DPRs, poly-GR and poly-PR, has been associated with nucleocytoplasmic transport. To investigate...

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Detalles Bibliográficos
Autores principales:	Vanneste, Joni, Vercruysse, Thomas, Boeynaems, Steven, Sicart, Adria, Van Damme, Philip, Daelemans, Dirk, Van Den Bosch, Ludo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823349/ https://www.ncbi.nlm.nih.gov/pubmed/31673013 http://dx.doi.org/10.1038/s41598-019-52035-6

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