Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca(2+)-bound nhTMEM16

Both lipid and ion translocation by Ca(2+)-regulated TMEM16 transmembrane proteins utilizes a membrane-exposed hydrophilic groove. Several conformations of the groove are observed in TMEM16 protein structures, but how these conformations form, and what functions they support, remains unknown. From a...

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Detalles Bibliográficos
Autores principales: Khelashvili, George, Falzone, Maria E., Cheng, Xiaolu, Lee, Byoung-Cheol, Accardi, Alessio, Weinstein, Harel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823365/
https://www.ncbi.nlm.nih.gov/pubmed/31672969
http://dx.doi.org/10.1038/s41467-019-12865-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823365/
https://www.ncbi.nlm.nih.gov/pubmed/31672969
http://dx.doi.org/10.1038/s41467-019-12865-4

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