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A multi-omics digital research object for the genetics of sleep regulation

With the aim to uncover the molecular pathways underlying the regulation of sleep, we recently assembled an extensive and comprehensive systems genetics dataset interrogating a genetic reference population of mice at the levels of the genome, the brain and liver transcriptomes, the plasma metabolome...

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Detalles Bibliográficos
Autores principales: Jan, Maxime, Gobet, Nastassia, Diessler, Shanaz, Franken, Paul, Xenarios, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823400/
https://www.ncbi.nlm.nih.gov/pubmed/31672980
http://dx.doi.org/10.1038/s41597-019-0171-x
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author Jan, Maxime
Gobet, Nastassia
Diessler, Shanaz
Franken, Paul
Xenarios, Ioannis
author_facet Jan, Maxime
Gobet, Nastassia
Diessler, Shanaz
Franken, Paul
Xenarios, Ioannis
author_sort Jan, Maxime
collection PubMed
description With the aim to uncover the molecular pathways underlying the regulation of sleep, we recently assembled an extensive and comprehensive systems genetics dataset interrogating a genetic reference population of mice at the levels of the genome, the brain and liver transcriptomes, the plasma metabolome, and the sleep-wake phenome. To facilitate a meaningful and efficient re-use of this public resource by others we designed, describe in detail, and made available a Digital Research Object (DRO), embedding data, documentation, and analytics. We present and discuss both the advantages and limitations of our multi-modal resource and analytic pipeline. The reproducibility of the results was tested by a bioinformatician not implicated in the original project and the robustness of results was assessed by re-annotating genetic and transcriptome data from the mm9 to the mm10 mouse genome assembly.
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spelling pubmed-68234002019-11-07 A multi-omics digital research object for the genetics of sleep regulation Jan, Maxime Gobet, Nastassia Diessler, Shanaz Franken, Paul Xenarios, Ioannis Sci Data Data Descriptor With the aim to uncover the molecular pathways underlying the regulation of sleep, we recently assembled an extensive and comprehensive systems genetics dataset interrogating a genetic reference population of mice at the levels of the genome, the brain and liver transcriptomes, the plasma metabolome, and the sleep-wake phenome. To facilitate a meaningful and efficient re-use of this public resource by others we designed, describe in detail, and made available a Digital Research Object (DRO), embedding data, documentation, and analytics. We present and discuss both the advantages and limitations of our multi-modal resource and analytic pipeline. The reproducibility of the results was tested by a bioinformatician not implicated in the original project and the robustness of results was assessed by re-annotating genetic and transcriptome data from the mm9 to the mm10 mouse genome assembly. Nature Publishing Group UK 2019-10-31 /pmc/articles/PMC6823400/ /pubmed/31672980 http://dx.doi.org/10.1038/s41597-019-0171-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the metadata files associated with this article.
spellingShingle Data Descriptor
Jan, Maxime
Gobet, Nastassia
Diessler, Shanaz
Franken, Paul
Xenarios, Ioannis
A multi-omics digital research object for the genetics of sleep regulation
title A multi-omics digital research object for the genetics of sleep regulation
title_full A multi-omics digital research object for the genetics of sleep regulation
title_fullStr A multi-omics digital research object for the genetics of sleep regulation
title_full_unstemmed A multi-omics digital research object for the genetics of sleep regulation
title_short A multi-omics digital research object for the genetics of sleep regulation
title_sort multi-omics digital research object for the genetics of sleep regulation
topic Data Descriptor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823400/
https://www.ncbi.nlm.nih.gov/pubmed/31672980
http://dx.doi.org/10.1038/s41597-019-0171-x
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