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Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer’s disease

Despite compelling evidence that the accumulation of amyloid-beta (Aβ) promotes neocortical MAPT (tau) aggregation in familial and idiopathic Alzheimer’s disease (AD), murine models of cerebral amyloidosis are not considered to develop tau-associated pathology. In the present study, we show that tau...

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Detalles Bibliográficos
Autores principales:	Metaxas, Athanasios, Thygesen, Camilla, Kempf, Stefan J., Anzalone, Marco, Vaitheeswaran, Ramanan, Petersen, Sussanne, Landau, Anne M., Audrain, Hélène, Teeling, Jessica L., Darvesh, Sultan, Brooks, David J., Larsen, Martin R., Finsen, Bente
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823454/ https://www.ncbi.nlm.nih.gov/pubmed/31673052 http://dx.doi.org/10.1038/s41598-019-52357-5

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