Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells

The mutagenic repair of Cas9 generated breaks is thought to predominantly rely on non-homologous end-joining (NHEJ), leading to insertions and deletions within DNA that culminate in gene knock-out (KO). In this study, by taking focused as well as genome-wide approaches, we show that this pathway is...

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Detalles Bibliográficos
Autores principales: Ferreira da Silva, Joana, Salic, Sejla, Wiedner, Marc, Datlinger, Paul, Essletzbichler, Patrick, Hanzl, Alexander, Superti-Furga, Giulio, Bock, Christoph, Winter, Georg, Loizou, Joanna I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823505/
https://www.ncbi.nlm.nih.gov/pubmed/31673055
http://dx.doi.org/10.1038/s41598-019-52078-9

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