Cargando…

“Close-to-Release”: Spontaneous Bioorthogonal Uncaging Resulting from Ring-Closing Metathesis

[Image: see text] Bioorthogonal uncaging reactions offer versatile tools in chemical biology. In recent years, reactions have been developed to proceed efficiently under physiological conditions. We present herein an uncaging reaction that results from ring-closing metathesis (RCM). A caged molecule...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sabatino, Valerio, Rebelein, Johannes G., Ward, Thomas R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823642/ https://www.ncbi.nlm.nih.gov/pubmed/31503474 http://dx.doi.org/10.1021/jacs.9b07193

Ejemplares similares

Supported Catalysts Useful in Ring-Closing Metathesis, Cross Metathesis, and Ring-Opening Metathesis Polymerization
por: Suriboot, Jakkrit, et al.
Publicado: (2016)

Bioorthogonal Uncaging of the Active Metabolite of Irinotecan by Palladium‐Functionalized Microdevices
por: Adam, Catherine, et al.
Publicado: (2018)

Kinetically E-Selective Macrocyclic Ring-Closing Metathesis
por: Shen, Xiao, et al.
Publicado: (2017)

Structural and Pharmacological Effects of Ring-Closing Metathesis in Peptides
por: Jacobsen, Øyvind, et al.
Publicado: (2010)

An efficient method for synthesising unsymmetrical silaketals: substrates for ring-closing, including macrocycle-closing, metathesis
por: Cordier, Christopher, et al.
Publicado: (2008)

Synthesis by Ring-Closing Metathesis and Cytotoxic Evaluation of Novel Thienylmacrolactones
por: Krauss, Jürgen, et al.
Publicado: (2012)

Ring-Closing Metathesis Approaches towards the Total Synthesis of Rhizoxins
por: Liniger, Marc, et al.
Publicado: (2020)

Bioorthogonal Uncaging of Cytotoxic Paclitaxel through Pd Nanosheet–Hydrogel Frameworks
por: Pérez-López, Ana M., et al.
Publicado: (2020)

Ring-closing-metathesis-based synthesis of annellated coumarins from 8-allylcoumarins
por: Schultze, Christiane, et al.
Publicado: (2018)

Functionalizable Stereocontrolled Cyclopolyethers by Ring‐Closing Metathesis as Natural Polymer Mimics
por: Alkattan, Mohammed, et al.
Publicado: (2018)

Advanced sol–gel process for efficient heterogeneous ring-closing metathesis
por: Aharon, Shiran, et al.
Publicado: (2021)

Silicon Catalyzed C−O Bond Ring Closing Metathesis of Polyethers
por: Ansmann, Nils, et al.
Publicado: (2022)

Biodegradable Grubbs-Loaded Artificial Organelles for Endosomal Ring-Closing Metathesis
por: Oerlemans, Roy A. J. F., et al.
Publicado: (2023)

The Tandem Ring Opening/Ring Closing Metathesis Route to Oxaspirocycles: An Approach to Phelligridin G
por: Cooper, Harold D., et al.
Publicado: (2013)

Synthesis of macrocyclic natural products by catalyst-controlled stereoselective ring-closing metathesis
por: Yu, Miao, et al.
Publicado: (2011)

Constraining an Irregular Peptide Secondary Structure through Ring‐Closing Alkyne Metathesis
por: Cromm, Philipp M., et al.
Publicado: (2016)

Polycyclic heteroaromatics via hydrazine-catalyzed ring-closing carbonyl–olefin metathesis
por: Cho, Eun Kee, et al.
Publicado: (2022)

Domino ring-opening–ring-closing enyne metathesis vs enyne metathesis of norbornene derivatives with alkynyl side chains. Construction of condensed polycarbocycles
por: Datta, Ritabrata, et al.
Publicado: (2018)

A Fluorous-Tagged “Safety Catch” Linker for Preparing Heterocycles by Ring-Closing Metathesis
por: O’Leary-Steele, Catherine, et al.
Publicado: (2009)

Homogeneous and Functional Group Tolerant Ring-Closing Metathesis for DNA-Encoded Chemical Libraries
por: Monty, Olivier B. C., et al.
Publicado: (2020)

Ring-closing C–O/C–O metathesis of ethers with primary aliphatic alcohols
por: Liu, Hongmei, et al.
Publicado: (2023)

Aqueous olefin metathesis: recent developments and applications
por: Sabatino, Valerio, et al.
Publicado: (2019)

Bidirectional cross metathesis and ring-closing metathesis/ring opening of a C(2)-symmetric building block: a strategy for the synthesis of decanolide natural products
por: Schmidt, Bernd, et al.
Publicado: (2013)

Synthesis of a Ribose‐Incorporating Medium Ring Scaffold via a Challenging Ring‐Closing Metathesis Reaction
por: Rankin, Stuart S., et al.
Publicado: (2016)

A short stereoselective synthesis of (+)-(6R,2′S)-cryptocaryalactone via ring-closing metathesis
por: Radha Krishna, Palakodety, et al.
Publicado: (2009)

Design and synthesis of novel bis-annulated caged polycycles via ring-closing metathesis: pushpakenediol
por: Kotha, Sambasivarao, et al.
Publicado: (2014)

Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
por: Cromm, Philipp M., et al.
Publicado: (2016)

Spiro annulation of cage polycycles via Grignard reaction and ring-closing metathesis as key steps
por: Kotha, Sambasivarao, et al.
Publicado: (2015)

Bridgehead vicinal diallylation of norbornene derivatives and extension to propellane derivatives via ring-closing metathesis
por: Kotha, Sambasivarao, et al.
Publicado: (2016)

Construction of Eight-Membered Carbocycles with Trisubstituted Double Bonds Using the Ring Closing Metathesis Reaction
por: Tori, Motoo, et al.
Publicado: (2010)

Supramolecular polymerization of a ureidopyrimidinone‐based [2]catenane prepared via ring‐closing metathesis
por: Teunissen, Abraham J. P., et al.
Publicado: (2017)

Dual Activity of Grubbs-Type Catalyst in the Transvinylation of Carboxylic Acids and Ring-Closing Metathesis Reactions
por: Brodzka, Anna, et al.
Publicado: (2020)

Synthesis of densely functionalized enantiopure indolizidines by ring-closing metathesis (RCM) of hydroxylamines from carbohydrate-derived nitrones
por: Bonanni, Marco, et al.
Publicado: (2007)

Tandem catalysis of ring-closing metathesis/atom transfer radical reactions with homobimetallic ruthenium–arene complexes
por: Borguet, Yannick, et al.
Publicado: (2010)

Toward a Simulation Approach for Alkene Ring-closing Metathesis: Scope and Limitations of a Model for RCM
por: Nelson, David J., et al.
Publicado: (2011)

Synthesis of Dihydropyrano[3,2-c]pyrazoles via Double Bond Migration and Ring-Closing Metathesis
por: Usami, Yoshihide, et al.
Publicado: (2019)

In Situ-Generated Niobium-Catalyzed Synthesis of 3-Pyrroline Derivatives via Ring-Closing Metathesis Reactions
por: Fuji, Maito, et al.
Publicado: (2018)

Formation of alkyne-bridged ferrocenophanes using ring-closing alkyne metathesis on 1,1’-diacetylenic ferrocenes
por: Bittner, Celine, et al.
Publicado: (2019)

Highly efficient Ru(ii)–alkylidene based Hoveyda–Grubbs catalysts for ring-closing metathesis reactions
por: Al-Enezi, Mariam Y., et al.
Publicado: (2021)

Synthetic Approach to the ABCD Ring System of Anticancer Agent Fredericamycin A via Claisen Rearrangement and Ring-Closing Metathesis as Key Steps
por: Kotha, Sambasivarao, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_re9pudtm2veavi4motturtstv7