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Deep Learning Implicitly Handles Tissue Specific Phenomena to Predict Tumor DNA Accessibility and Immune Activity

DNA accessibility is a key dynamic feature of chromatin regulation that can potentiate transcriptional events and tumor progression. To gain insight into chromatin state across existing tumor data, we improved neural network models for predicting accessibility from DNA sequence and extended them to...

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Detalles Bibliográficos
Autores principales:	Wnuk, Kamil, Sudol, Jeremi, Givechian, Kevin B., Soon-Shiong, Patrick, Rabizadeh, Shahrooz, Szeto, Christopher, Vaske, Charles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823659/ https://www.ncbi.nlm.nih.gov/pubmed/31563852 http://dx.doi.org/10.1016/j.isci.2019.09.018

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