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Head and neck cancer management and cancer stem cells implication
Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the upper aerodigestive tract and are heterogeneous in nature. Risk factors for HNSCCs are smoking, excessive alcohol consumption, and the human papilloma virus. Conventional treatments are surgery, radiotherapy, chemoth...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823822/ https://www.ncbi.nlm.nih.gov/pubmed/31700218 http://dx.doi.org/10.1016/j.sdentj.2019.05.010 |
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author | Elkashty, Osama A. Ashry, Ramy Tran, Simon D. |
author_facet | Elkashty, Osama A. Ashry, Ramy Tran, Simon D. |
author_sort | Elkashty, Osama A. |
collection | PubMed |
description | Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the upper aerodigestive tract and are heterogeneous in nature. Risk factors for HNSCCs are smoking, excessive alcohol consumption, and the human papilloma virus. Conventional treatments are surgery, radiotherapy, chemotherapy, or a combined modality; however, no international standard mode of therapy exists. In contrast to the conventional model of clonal evolution in tumor development, there is a newly proposed theory based on the activity of cancer stem cells (CSCs) as the model for carcinogenesis. This “CSC hypothesis” may explain the high mortality rate, low response to treatments, and tendency to develop multiple tumors for HNSCC patients. We review current knowledge on HNSCC etiology and treatment, with a focus on CSCs, including their origins, identifications, and effects on therapeutic options. |
format | Online Article Text |
id | pubmed-6823822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-68238222019-11-07 Head and neck cancer management and cancer stem cells implication Elkashty, Osama A. Ashry, Ramy Tran, Simon D. Saudi Dent J Review Article Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the upper aerodigestive tract and are heterogeneous in nature. Risk factors for HNSCCs are smoking, excessive alcohol consumption, and the human papilloma virus. Conventional treatments are surgery, radiotherapy, chemotherapy, or a combined modality; however, no international standard mode of therapy exists. In contrast to the conventional model of clonal evolution in tumor development, there is a newly proposed theory based on the activity of cancer stem cells (CSCs) as the model for carcinogenesis. This “CSC hypothesis” may explain the high mortality rate, low response to treatments, and tendency to develop multiple tumors for HNSCC patients. We review current knowledge on HNSCC etiology and treatment, with a focus on CSCs, including their origins, identifications, and effects on therapeutic options. Elsevier 2019-10 2019-06-10 /pmc/articles/PMC6823822/ /pubmed/31700218 http://dx.doi.org/10.1016/j.sdentj.2019.05.010 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Elkashty, Osama A. Ashry, Ramy Tran, Simon D. Head and neck cancer management and cancer stem cells implication |
title | Head and neck cancer management and cancer stem cells implication |
title_full | Head and neck cancer management and cancer stem cells implication |
title_fullStr | Head and neck cancer management and cancer stem cells implication |
title_full_unstemmed | Head and neck cancer management and cancer stem cells implication |
title_short | Head and neck cancer management and cancer stem cells implication |
title_sort | head and neck cancer management and cancer stem cells implication |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823822/ https://www.ncbi.nlm.nih.gov/pubmed/31700218 http://dx.doi.org/10.1016/j.sdentj.2019.05.010 |
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