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Head and neck cancer management and cancer stem cells implication

Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the upper aerodigestive tract and are heterogeneous in nature. Risk factors for HNSCCs are smoking, excessive alcohol consumption, and the human papilloma virus. Conventional treatments are surgery, radiotherapy, chemoth...

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Detalles Bibliográficos
Autores principales: Elkashty, Osama A., Ashry, Ramy, Tran, Simon D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823822/
https://www.ncbi.nlm.nih.gov/pubmed/31700218
http://dx.doi.org/10.1016/j.sdentj.2019.05.010
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author Elkashty, Osama A.
Ashry, Ramy
Tran, Simon D.
author_facet Elkashty, Osama A.
Ashry, Ramy
Tran, Simon D.
author_sort Elkashty, Osama A.
collection PubMed
description Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the upper aerodigestive tract and are heterogeneous in nature. Risk factors for HNSCCs are smoking, excessive alcohol consumption, and the human papilloma virus. Conventional treatments are surgery, radiotherapy, chemotherapy, or a combined modality; however, no international standard mode of therapy exists. In contrast to the conventional model of clonal evolution in tumor development, there is a newly proposed theory based on the activity of cancer stem cells (CSCs) as the model for carcinogenesis. This “CSC hypothesis” may explain the high mortality rate, low response to treatments, and tendency to develop multiple tumors for HNSCC patients. We review current knowledge on HNSCC etiology and treatment, with a focus on CSCs, including their origins, identifications, and effects on therapeutic options.
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spelling pubmed-68238222019-11-07 Head and neck cancer management and cancer stem cells implication Elkashty, Osama A. Ashry, Ramy Tran, Simon D. Saudi Dent J Review Article Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the upper aerodigestive tract and are heterogeneous in nature. Risk factors for HNSCCs are smoking, excessive alcohol consumption, and the human papilloma virus. Conventional treatments are surgery, radiotherapy, chemotherapy, or a combined modality; however, no international standard mode of therapy exists. In contrast to the conventional model of clonal evolution in tumor development, there is a newly proposed theory based on the activity of cancer stem cells (CSCs) as the model for carcinogenesis. This “CSC hypothesis” may explain the high mortality rate, low response to treatments, and tendency to develop multiple tumors for HNSCC patients. We review current knowledge on HNSCC etiology and treatment, with a focus on CSCs, including their origins, identifications, and effects on therapeutic options. Elsevier 2019-10 2019-06-10 /pmc/articles/PMC6823822/ /pubmed/31700218 http://dx.doi.org/10.1016/j.sdentj.2019.05.010 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Elkashty, Osama A.
Ashry, Ramy
Tran, Simon D.
Head and neck cancer management and cancer stem cells implication
title Head and neck cancer management and cancer stem cells implication
title_full Head and neck cancer management and cancer stem cells implication
title_fullStr Head and neck cancer management and cancer stem cells implication
title_full_unstemmed Head and neck cancer management and cancer stem cells implication
title_short Head and neck cancer management and cancer stem cells implication
title_sort head and neck cancer management and cancer stem cells implication
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823822/
https://www.ncbi.nlm.nih.gov/pubmed/31700218
http://dx.doi.org/10.1016/j.sdentj.2019.05.010
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