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Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin

Objective: The human intestinal microbiome plays an important role in inflammatory bowel disease (IBD) and colorectal cancer (CRC) development. One of the first discovered bacterial mediators involves Bacteroides fragilis toxin (BFT, also named as fragilysin), a metalloprotease encoded by enterotoxi...

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Detalles Bibliográficos
Autores principales:	Metz, Paul, Tjan, Martijn J. H., Wu, Shaoguang, Pervaiz, Mehrosh, Hermans, Susanne, Shettigar, Aishwarya, Sears, Cynthia L., Ritschel, Tina, Dutilh, Bas E., Boleij, Annemarie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823872/ https://www.ncbi.nlm.nih.gov/pubmed/31709196 http://dx.doi.org/10.3389/fcimb.2019.00364

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