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Dietary-phytochemical mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer

BACKGROUND: The deregulated alternative splicing of key glycolytic enzyme, Pyruvate Kinase muscle isoenzyme (PKM) is implicated in metabolic adaptation of cancer cells. The splicing switch from normal PKM1 to cancer-specific PKM2 isoform allows the cancer cells to meet their energy and biosynthetic...

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Detalles Bibliográficos
Autores principales:	Yadav, Sandhya, Bhagat, Somnath D., Gupta, Amit, Samaiya, Atul, Srivastava, Aasheesh, Shukla, Sanjeev
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823945/ https://www.ncbi.nlm.nih.gov/pubmed/31675998 http://dx.doi.org/10.1186/s12885-019-6257-1

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