Cargando…
Mortality risk of bloodstream infection caused by either Escherichia coli or Klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort study
OBJECTIVE: Several studies reported that infection of extended-spectrum β lactamase (ESBL)-producing Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae) contributed to higher mortality rates but others found it was not associated with mortality. A prospective cohort study which invol...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824086/ https://www.ncbi.nlm.nih.gov/pubmed/31675991 http://dx.doi.org/10.1186/s13104-019-4751-9 |
_version_ | 1783464669492543488 |
---|---|
author | Sianipar, Osman Asmara, Widya Dwiprahasto, Iwan Mulyono, Budi |
author_facet | Sianipar, Osman Asmara, Widya Dwiprahasto, Iwan Mulyono, Budi |
author_sort | Sianipar, Osman |
collection | PubMed |
description | OBJECTIVE: Several studies reported that infection of extended-spectrum β lactamase (ESBL)-producing Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae) contributed to higher mortality rates but others found it was not associated with mortality. A prospective cohort study which involved 72 patients was conducted to assess the risk of mortality of bloodstream infection due to ESBL-producing K. pneumoniae or E. coli as compared to those infected by either K. pneumoniae or E. coli which not produce ESBL. RESULT: Mortality in the group of patients infected with ESBL-producing bacteria was 30.6%, whereas in another group which was infected with non ESBL-producing bacteria was 22.2% (p = 0.59). Kaplan–Meier’s analysis showed that the survival rate during 14-days follow-up among these two group was not significantly different (p = 0.45) with hazard ratio 1.41 (95% CI 0.568–3.51). Stratification analysis found that adult and elderly patients, patients with sign of leukocytosis, and patients treated with carbapenem were modifier effect variables. |
format | Online Article Text |
id | pubmed-6824086 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-68240862019-11-06 Mortality risk of bloodstream infection caused by either Escherichia coli or Klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort study Sianipar, Osman Asmara, Widya Dwiprahasto, Iwan Mulyono, Budi BMC Res Notes Research Note OBJECTIVE: Several studies reported that infection of extended-spectrum β lactamase (ESBL)-producing Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae) contributed to higher mortality rates but others found it was not associated with mortality. A prospective cohort study which involved 72 patients was conducted to assess the risk of mortality of bloodstream infection due to ESBL-producing K. pneumoniae or E. coli as compared to those infected by either K. pneumoniae or E. coli which not produce ESBL. RESULT: Mortality in the group of patients infected with ESBL-producing bacteria was 30.6%, whereas in another group which was infected with non ESBL-producing bacteria was 22.2% (p = 0.59). Kaplan–Meier’s analysis showed that the survival rate during 14-days follow-up among these two group was not significantly different (p = 0.45) with hazard ratio 1.41 (95% CI 0.568–3.51). Stratification analysis found that adult and elderly patients, patients with sign of leukocytosis, and patients treated with carbapenem were modifier effect variables. BioMed Central 2019-11-01 /pmc/articles/PMC6824086/ /pubmed/31675991 http://dx.doi.org/10.1186/s13104-019-4751-9 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Note Sianipar, Osman Asmara, Widya Dwiprahasto, Iwan Mulyono, Budi Mortality risk of bloodstream infection caused by either Escherichia coli or Klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort study |
title | Mortality risk of bloodstream infection caused by either Escherichia coli or Klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort study |
title_full | Mortality risk of bloodstream infection caused by either Escherichia coli or Klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort study |
title_fullStr | Mortality risk of bloodstream infection caused by either Escherichia coli or Klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort study |
title_full_unstemmed | Mortality risk of bloodstream infection caused by either Escherichia coli or Klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort study |
title_short | Mortality risk of bloodstream infection caused by either Escherichia coli or Klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort study |
title_sort | mortality risk of bloodstream infection caused by either escherichia coli or klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort study |
topic | Research Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824086/ https://www.ncbi.nlm.nih.gov/pubmed/31675991 http://dx.doi.org/10.1186/s13104-019-4751-9 |
work_keys_str_mv | AT sianiparosman mortalityriskofbloodstreaminfectioncausedbyeitherescherichiacoliorklebsiellapneumoniaeproducingextendedspectrumblactamaseaprospectivecohortstudy AT asmarawidya mortalityriskofbloodstreaminfectioncausedbyeitherescherichiacoliorklebsiellapneumoniaeproducingextendedspectrumblactamaseaprospectivecohortstudy AT dwiprahastoiwan mortalityriskofbloodstreaminfectioncausedbyeitherescherichiacoliorklebsiellapneumoniaeproducingextendedspectrumblactamaseaprospectivecohortstudy AT mulyonobudi mortalityriskofbloodstreaminfectioncausedbyeitherescherichiacoliorklebsiellapneumoniaeproducingextendedspectrumblactamaseaprospectivecohortstudy |