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Lynch syndrome–associated ultra-hypermutated pediatric glioblastoma mimicking a constitutional mismatch repair deficiency syndrome

Pediatric glioblastoma multiforme (GBM) has a poor prognosis as a result of recurrence after treatment of surgery and radiochemotherapy. A small subset of pediatric GBMs presenting with an ultra-high tumor mutational burden (TMB) may be sensitive to immune checkpoint inhibition. Here we report a 16-...

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Detalles Bibliográficos
Autores principales:	Yang, Chen, Austin, Frances, Richard, Hope, Idowu, Michael, Williamson, Vernell, Sabato, Fernanda, Ferreira-Gonzalez, Andrea, Turner, Scott A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2019
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824252/ https://www.ncbi.nlm.nih.gov/pubmed/31604779 http://dx.doi.org/10.1101/mcs.a003863

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