Cargando…
Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor
Gliomatosis peritonei is a rare pathologic finding that is associated with ovarian teratomas and malignant mixed germ cell tumors. The occurrence of gliomatosis as a mature glial implant can impart an improved prognosis to patients with immature ovarian teratoma, making prompt and accurate diagnosis...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824255/ https://www.ncbi.nlm.nih.gov/pubmed/31645344 http://dx.doi.org/10.1101/mcs.a004317 |
| _version_ | 1783464706527199232 |
|---|---|
| author | Sanders, Lauren M. Rangaswami, Arun Bjork, Isabel Lam, Du Linh Beale, Holly C. Kephart, Ellen Towle Durbin, Ann Learned, Katrina Currie, Rob Lyle, A. Geoffrey Pfeil, Jacob Shah, Avanthi Tayi Lee, Alex G. Leung, Stanley G. Behroozfard, Inge H. Breese, Marcus R. Peralez, Jennifer Hazard, Florette K. Lacayo, Norman Spunt, Sheri L. Haussler, David Salama, Sofie R. Sweet-Cordero, E. Alejandro Vaske, Olena M. |
| author_facet | Sanders, Lauren M. Rangaswami, Arun Bjork, Isabel Lam, Du Linh Beale, Holly C. Kephart, Ellen Towle Durbin, Ann Learned, Katrina Currie, Rob Lyle, A. Geoffrey Pfeil, Jacob Shah, Avanthi Tayi Lee, Alex G. Leung, Stanley G. Behroozfard, Inge H. Breese, Marcus R. Peralez, Jennifer Hazard, Florette K. Lacayo, Norman Spunt, Sheri L. Haussler, David Salama, Sofie R. Sweet-Cordero, E. Alejandro Vaske, Olena M. |
| author_sort | Sanders, Lauren M. |
| collection | PubMed |
| description | Gliomatosis peritonei is a rare pathologic finding that is associated with ovarian teratomas and malignant mixed germ cell tumors. The occurrence of gliomatosis as a mature glial implant can impart an improved prognosis to patients with immature ovarian teratoma, making prompt and accurate diagnosis important. We describe a case of recurrent immature teratoma in a 10-yr-old female patient, in which comparative analysis of the RNA sequencing gene expression data from the patient's tumor was used effectively to aid in the diagnosis of gliomatosis peritonei. |
| format | Online Article Text |
| id | pubmed-6824255 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Cold Spring Harbor Laboratory Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-68242552019-11-15 Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor Sanders, Lauren M. Rangaswami, Arun Bjork, Isabel Lam, Du Linh Beale, Holly C. Kephart, Ellen Towle Durbin, Ann Learned, Katrina Currie, Rob Lyle, A. Geoffrey Pfeil, Jacob Shah, Avanthi Tayi Lee, Alex G. Leung, Stanley G. Behroozfard, Inge H. Breese, Marcus R. Peralez, Jennifer Hazard, Florette K. Lacayo, Norman Spunt, Sheri L. Haussler, David Salama, Sofie R. Sweet-Cordero, E. Alejandro Vaske, Olena M. Cold Spring Harb Mol Case Stud Research Report Gliomatosis peritonei is a rare pathologic finding that is associated with ovarian teratomas and malignant mixed germ cell tumors. The occurrence of gliomatosis as a mature glial implant can impart an improved prognosis to patients with immature ovarian teratoma, making prompt and accurate diagnosis important. We describe a case of recurrent immature teratoma in a 10-yr-old female patient, in which comparative analysis of the RNA sequencing gene expression data from the patient's tumor was used effectively to aid in the diagnosis of gliomatosis peritonei. Cold Spring Harbor Laboratory Press 2019-10 /pmc/articles/PMC6824255/ /pubmed/31645344 http://dx.doi.org/10.1101/mcs.a004317 Text en © 2019 Sanders et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/) , which permits reuse and redistribution, except for commercial purposes, provided that the original author and source are credited. |
| spellingShingle | Research Report Sanders, Lauren M. Rangaswami, Arun Bjork, Isabel Lam, Du Linh Beale, Holly C. Kephart, Ellen Towle Durbin, Ann Learned, Katrina Currie, Rob Lyle, A. Geoffrey Pfeil, Jacob Shah, Avanthi Tayi Lee, Alex G. Leung, Stanley G. Behroozfard, Inge H. Breese, Marcus R. Peralez, Jennifer Hazard, Florette K. Lacayo, Norman Spunt, Sheri L. Haussler, David Salama, Sofie R. Sweet-Cordero, E. Alejandro Vaske, Olena M. Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor |
| title | Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor |
| title_full | Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor |
| title_fullStr | Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor |
| title_full_unstemmed | Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor |
| title_short | Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor |
| title_sort | comparative rna-seq analysis aids in diagnosis of a rare pediatric tumor |
| topic | Research Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824255/ https://www.ncbi.nlm.nih.gov/pubmed/31645344 http://dx.doi.org/10.1101/mcs.a004317 |
| work_keys_str_mv | AT sanderslaurenm comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT rangaswamiarun comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT bjorkisabel comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT lamdulinh comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT bealehollyc comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT kephartellentowle comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT durbinann comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT learnedkatrina comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT currierob comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT lyleageoffrey comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT pfeiljacob comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT shahavanthitayi comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT leealexg comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT leungstanleyg comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT behroozfardingeh comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT breesemarcusr comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT peralezjennifer comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT hazardflorettek comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT lacayonorman comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT spuntsheril comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT hausslerdavid comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT salamasofier comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT sweetcorderoealejandro comparativernaseqanalysisaidsindiagnosisofararepediatrictumor AT vaskeolenam comparativernaseqanalysisaidsindiagnosisofararepediatrictumor |