GLP-1 Receptor Activation Abrogates β-Cell Dysfunction by PKA Cα-Mediated Degradation of Thioredoxin Interacting Protein

Glucagon-like peptide 1 receptor (GLP-1R) agonist (Exendin-4) is a well-known agent used to improve β-cell dysfunctions via protein kinase A (PKA), but the detailed downstream molecular mechanisms are still elusive. We have now found that PKA Cα mediated- TXNIP phosphorylation and degradation played...

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Detalles Bibliográficos
Autores principales: He, Shijun, Wu, Wenyu, Wan, Yihong, Nandakumar, Kutty Selva, Cai, Xiuchao, Tang, Xiaodong, Liu, Shuwen, Yao, Xingang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824261/
https://www.ncbi.nlm.nih.gov/pubmed/31708773
http://dx.doi.org/10.3389/fphar.2019.01230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824261/
https://www.ncbi.nlm.nih.gov/pubmed/31708773
http://dx.doi.org/10.3389/fphar.2019.01230

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