Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity

Itch induces scratching that removes irritants from the skin, whereas pain initiates withdrawal or avoidance of tissue damage. While pain arises from both the skin and viscera, we investigated whether pruritogenic irritant mechanisms also function within visceral pathways. We show that subsets of co...

Descripción completa

Detalles Bibliográficos
Autores principales: Castro, Joel, Harrington, Andrea M., Lieu, TinaMarie, Garcia-Caraballo, Sonia, Maddern, Jessica, Schober, Gudrun, O’Donnell, Tracey, Grundy, Luke, Lumsden, Amanda L., Miller, Paul, Ghetti, Andre, Steinhoff, Martin S., Poole, Daniel P., Dong, Xinzhong, Chang, Lin, Bunnett, Nigel W., Brierley, Stuart M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824308/
https://www.ncbi.nlm.nih.gov/pubmed/31536477
http://dx.doi.org/10.1172/jci.insight.131712

Ejemplares similares

Ejemplares similares