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Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling
Genome rearrangements that occur during evolution impose major challenges on regulatory mechanisms that rely on three-dimensional genome architecture. Here, we developed a scaffolding algorithm and generated chromosome-length assemblies from Hi-C data for studying genome topology in three distantly...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824461/ https://www.ncbi.nlm.nih.gov/pubmed/31601616 http://dx.doi.org/10.1101/gad.328971.119 |