Metabolic dependencies and vulnerabilities in leukemia

Leukemia cell proliferation requires up-regulation and rewiring of metabolic pathways to feed anabolic cell growth. Oncogenic drivers directly and indirectly regulate metabolic pathways, and aberrant metabolism is central not only for leukemia proliferation and survival, but also mediates oncogene a...

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Detalles Bibliográficos
Autores principales: Rashkovan, Marissa, Ferrando, Adolfo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824464/
https://www.ncbi.nlm.nih.gov/pubmed/31676734
http://dx.doi.org/10.1101/gad.326470.119
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author Rashkovan, Marissa
Ferrando, Adolfo
author_facet Rashkovan, Marissa
Ferrando, Adolfo
author_sort Rashkovan, Marissa
collection PubMed
description Leukemia cell proliferation requires up-regulation and rewiring of metabolic pathways to feed anabolic cell growth. Oncogenic drivers directly and indirectly regulate metabolic pathways, and aberrant metabolism is central not only for leukemia proliferation and survival, but also mediates oncogene addiction with significant implications for the development of targeted therapies. This review explores leukemia metabolic circuitries feeding anabolism, redox potential, and energy required for tumor propagation with an emphasis on emerging therapeutic opportunities.
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spelling pubmed-68244642019-11-15 Metabolic dependencies and vulnerabilities in leukemia Rashkovan, Marissa Ferrando, Adolfo Genes Dev Review Leukemia cell proliferation requires up-regulation and rewiring of metabolic pathways to feed anabolic cell growth. Oncogenic drivers directly and indirectly regulate metabolic pathways, and aberrant metabolism is central not only for leukemia proliferation and survival, but also mediates oncogene addiction with significant implications for the development of targeted therapies. This review explores leukemia metabolic circuitries feeding anabolism, redox potential, and energy required for tumor propagation with an emphasis on emerging therapeutic opportunities. Cold Spring Harbor Laboratory Press 2019-11-01 /pmc/articles/PMC6824464/ /pubmed/31676734 http://dx.doi.org/10.1101/gad.326470.119 Text en © 2019 Rashkovan and Ferrando; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article, published in Genes & Development, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Rashkovan, Marissa
Ferrando, Adolfo
Metabolic dependencies and vulnerabilities in leukemia
title Metabolic dependencies and vulnerabilities in leukemia
title_full Metabolic dependencies and vulnerabilities in leukemia
title_fullStr Metabolic dependencies and vulnerabilities in leukemia
title_full_unstemmed Metabolic dependencies and vulnerabilities in leukemia
title_short Metabolic dependencies and vulnerabilities in leukemia
title_sort metabolic dependencies and vulnerabilities in leukemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824464/
https://www.ncbi.nlm.nih.gov/pubmed/31676734
http://dx.doi.org/10.1101/gad.326470.119
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