Cargando…

Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling

TGF-β receptors phosphorylate SMAD2 and SMAD3 transcription factors, which then form heterotrimeric complexes with SMAD4 and cooperate with context-specific transcription factors to activate target genes. Here we provide biochemical and structural evidence showing that binding of SMAD2 to DNA depend...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aragón, Eric, Wang, Qiong, Zou, Yilong, Morgani, Sophie M., Ruiz, Lidia, Kaczmarska, Zuzanna, Su, Jie, Torner, Carles, Tian, Lin, Hu, Jing, Shu, Weiping, Agrawal, Saloni, Gomes, Tiago, Márquez, José A., Hadjantonakis, Anna-Katerina, Macias, Maria J., Massagué, Joan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824466/ https://www.ncbi.nlm.nih.gov/pubmed/31582430 http://dx.doi.org/10.1101/gad.330837.119

Ejemplares similares

Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1
por: Pluta, Radoslaw, et al.
Publicado: (2022)

Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes
por: Ruiz, Lidia, et al.
Publicado: (2021)

Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors
por: Martin-Malpartida, Pau, et al.
Publicado: (2017)

TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling
por: Guca, Ewelina, et al.
Publicado: (2018)

Conformational landscape of multidomain SMAD proteins
por: Gomes, Tiago, et al.
Publicado: (2021)

The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos
por: Morgani, Sophie M, et al.
Publicado: (2021)

AB198. Nodal regulates the differentiation of iPS cells to male germ cells via Smad2/3, Oct4 and Foxh1 activation
por: Yang, Shi, et al.
Publicado: (2014)

TGF-Beta Induced Erk Phosphorylation of Smad Linker Region Regulates Smad Signaling
por: Hough, Chris, et al.
Publicado: (2012)

SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
por: Bertrand-Chapel, Adrien, et al.
Publicado: (2022)

The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas
por: Zhenye, Li, et al.
Publicado: (2014)

Effect of progesterone on Smad signaling and TGF-β/Smad-regulated genes in lung epithelial cells
por: Kunzmann, Steffen, et al.
Publicado: (2018)

TGF-β/Smad signaling in renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2015)

Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-β/SMAD pathway
por: Kang, Heeseog, et al.
Publicado: (2020)

Smad4-mediated TGF-β signaling in tumorigenesis
por: Yang, Guan, et al.
Publicado: (2010)

The regulation of TGF-β/SMAD signaling by protein deubiquitination
por: Zhang, Juan, et al.
Publicado: (2014)

The role of TGF-β/SMAD4 signaling in cancer
por: Zhao, Ming, et al.
Publicado: (2018)

TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis
por: Yu, Xiao-Yong, et al.
Publicado: (2022)

Spatio-Temporal Distribution of Smads and Role of Smads/TGF-β/BMP-4 in the Regulation of Mouse Bladder Organogenesis
por: Islam, Syed S., et al.
Publicado: (2013)

TGF-β2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells’ invasion
por: Zhang, Chao, et al.
Publicado: (2017)

Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways
por: Hernández-Aquino, Erika, et al.
Publicado: (2017)

TGF‐β1 promotes gap junctions formation in chondrocytes via Smad3/Smad4 signalling
por: Wang, Qingxuan, et al.
Publicado: (2018)

A Novel TGFβ Modulator that Uncouples R-Smad/I-Smad-Mediated Negative Feedback from R-Smad/Ligand-Driven Positive Feedback
por: Gu, Wenchao, et al.
Publicado: (2015)

Latency-Associated Transcript-Derived MicroRNAs in Herpes Simplex Virus Type 1 Target SMAD3 and SMAD4 in TGF-β/Smad Signaling Pathway
por: Shojaei Jeshvaghani, Zahra, et al.
Publicado: (2021)

Aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway in intrauterine adhesions
por: Zhang, Zihui, et al.
Publicado: (2020)

Quantitative analysis of signaling responses during mouse primordial germ cell specification
por: Morgani, Sophie M., et al.
Publicado: (2021)

The Smads
por: Attisano, Liliana, et al.
Publicado: (2001)

Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation
por: Lan, Hui Yao
Publicado: (2011)

Roles of TGFβ signaling Smads in squamous cell carcinoma
por: Han, Gangwen, et al.
Publicado: (2011)

Non-degradative ubiquitination in Smad-dependent TGF-β signaling
por: Tang, Liu-Ya, et al.
Publicado: (2011)

Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination
por: Xie, Feng, et al.
Publicado: (2014)

Rejuvenation by inhibiting TGF-β1/pSmad signaling
por: Corder, Elizabeth H., et al.
Publicado: (2015)

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis
por: Walton, Kelly L., et al.
Publicado: (2017)

TGF-β/Smad Signalling in Neurogenesis: Implications for Neuropsychiatric Diseases
por: Hiew, Lih-Fhung, et al.
Publicado: (2021)

Immunohistochemical Expression of TGF-Β1, SMAD4, SMAD7, TGFβRII and CD68-Positive TAM Densities in Papillary Thyroid Cancer
por: Ivanova, Koni, et al.
Publicado: (2018)

It’s a SMAD, SMAD World: Cell Type–Specific SMAD Signaling in the Heart
por: Bradshaw, Amy D.
Publicado: (2019)

BRCA1 Interacts with Smad3 and Regulates Smad3-Mediated TGF-β Signaling during Oxidative Stress Responses
por: Li, Huchun, et al.
Publicado: (2009)

Alcohol Activates TGF-Beta but Inhibits BMP Receptor-Mediated Smad Signaling and Smad4 Binding to Hepcidin Promoter in the Liver
por: Gerjevic, Lisa Nicole, et al.
Publicado: (2012)

Smad2 and Smad3 have differential sensitivity in relaying TGFβ signaling and inversely regulate early lineage specification
por: Liu, Ling, et al.
Publicado: (2016)

TrkB-Induced Inhibition of R-SMAD/SMAD4 Activation is Essential for TGF-β-Mediated Tumor Suppressor Activity
por: Kim, Min Soo, et al.
Publicado: (2020)

Retraction Note: TGF-β2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells’ invasion
por: Zhang, Chao, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_18r64370sbh4ldpvf8gelrasru