Cargando…
Ang-(1-7)/ MAS1 receptor axis inhibits allergic airway inflammation via blockade of Src-mediated EGFR transactivation in a murine model of asthma
The angiotensin-(1–7) [Ang-(1–7)]/MAS1 receptor signaling axis is a key endogenous anti-inflammatory signaling pathway. However, the mechanisms by which its mediates the anti-inflammatory effects are not completely understood. Using an allergic murine model of asthma, we investigated whether Ang-1(1...
Autores principales: | El-Hashim, Ahmed Z., Khajah, Maitham A., Babyson, Rhema S., Renno, Waleed M., Ezeamuzie, Charles I., Benter, Ibrahim F., Akhtar, Saghir |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824568/ https://www.ncbi.nlm.nih.gov/pubmed/31675376 http://dx.doi.org/10.1371/journal.pone.0224163 |
Ejemplares similares
-
Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2, PI3Kδ/Akt and NFκB induction in a murine asthma model
por: El-Hashim, Ahmed Z., et al.
Publicado: (2017) -
Transactivation of ErbB Family of Receptor Tyrosine Kinases Is Inhibited by Angiotensin-(1-7) via Its Mas Receptor
por: Akhtar, Saghir, et al.
Publicado: (2015) -
Chronic Treatment with Ang-(1-7) Reverses Abnormal Reactivity in the Corpus Cavernosum and Normalizes Diabetes-Induced Changes in the Protein Levels of ACE, ACE2, ROCK1, ROCK2 and Omega-Hydroxylase in a Rat Model of Type 1 Diabetes
por: Yousif, Mariam H. M., et al.
Publicado: (2014) -
Mitigating Cardiotoxicity of Dendrimers: Angiotensin-(1-7) via Its Mas Receptor Ameliorates PAMAM-Induced Cardiac Dysfunction in the Isolated Mammalian Heart
por: Akhtar, Saghir, et al.
Publicado: (2022) -
Onion Bulb Extract Downregulates EGFR/ERK1/2/AKT Signaling Pathway and Synergizes With Steroids to Inhibit Allergic Inflammation
por: El-Hashim, Ahmed Z., et al.
Publicado: (2020)