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Anxiety and depression predict unfavorable survival in acute myeloid leukemia patients

This study aimed to investigate the prevalence/severity of anxiety and depression, and also their correlations with clinical characteristics and survival profiles in acute myeloid leukemia (AML) patients. In all, 208 AML patients and 200 age and sex-matched healthy controls (HCs) were recruited in t...

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Autores principales: Ding, Ting, Wang, Xin, Fu, Adan, Xu, Liwen, Lin, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824643/
https://www.ncbi.nlm.nih.gov/pubmed/31651837
http://dx.doi.org/10.1097/MD.0000000000017314
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author Ding, Ting
Wang, Xin
Fu, Adan
Xu, Liwen
Lin, Jing
author_facet Ding, Ting
Wang, Xin
Fu, Adan
Xu, Liwen
Lin, Jing
author_sort Ding, Ting
collection PubMed
description This study aimed to investigate the prevalence/severity of anxiety and depression, and also their correlations with clinical characteristics and survival profiles in acute myeloid leukemia (AML) patients. In all, 208 AML patients and 200 age and sex-matched healthy controls (HCs) were recruited in this study. Anxiety and depression were assessed by the Hospital Anxiety and Depression Scale (HADS) in AML patients before initiating therapy and in HCs after being enrolled. Treatment response was assessed, and event-free survival (EFS), and also the overall survival (OS) were calculated. The HADS-anxiety score (P < .001), anxiety prevalence (P < .001), and anxiety severity (P < .001) were increased in AML patients than those in HCs. The HADS-depression score (P < .001), depression prevalence (P < .001), and also depression severity (P < .001) were higher in AML patients compared with HCs. No correlation of anxiety or depression with clinical characteristics was found in AML patients (all P > .05). Moreover, the anxiety (P = .178) and depression (P = .512) rates were similar between complete remission (CR) patients and non-CR patients. Additionally, the EFS was worse in anxiety patients compared with nonanxiety patients (P = .013). The OS was shorter in anxiety patients compared with nonanxiety patients (P = .015) and was also worse in depression patients compared with nondepression patients (P = .007). Anxiety and depression are much more frequent and severe in AML patients compared to HCs, and both of them predict unfavorable survival profiles in AML patients.
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spelling pubmed-68246432019-11-19 Anxiety and depression predict unfavorable survival in acute myeloid leukemia patients Ding, Ting Wang, Xin Fu, Adan Xu, Liwen Lin, Jing Medicine (Baltimore) 4800 This study aimed to investigate the prevalence/severity of anxiety and depression, and also their correlations with clinical characteristics and survival profiles in acute myeloid leukemia (AML) patients. In all, 208 AML patients and 200 age and sex-matched healthy controls (HCs) were recruited in this study. Anxiety and depression were assessed by the Hospital Anxiety and Depression Scale (HADS) in AML patients before initiating therapy and in HCs after being enrolled. Treatment response was assessed, and event-free survival (EFS), and also the overall survival (OS) were calculated. The HADS-anxiety score (P < .001), anxiety prevalence (P < .001), and anxiety severity (P < .001) were increased in AML patients than those in HCs. The HADS-depression score (P < .001), depression prevalence (P < .001), and also depression severity (P < .001) were higher in AML patients compared with HCs. No correlation of anxiety or depression with clinical characteristics was found in AML patients (all P > .05). Moreover, the anxiety (P = .178) and depression (P = .512) rates were similar between complete remission (CR) patients and non-CR patients. Additionally, the EFS was worse in anxiety patients compared with nonanxiety patients (P = .013). The OS was shorter in anxiety patients compared with nonanxiety patients (P = .015) and was also worse in depression patients compared with nondepression patients (P = .007). Anxiety and depression are much more frequent and severe in AML patients compared to HCs, and both of them predict unfavorable survival profiles in AML patients. Wolters Kluwer Health 2019-10-25 /pmc/articles/PMC6824643/ /pubmed/31651837 http://dx.doi.org/10.1097/MD.0000000000017314 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 4800
Ding, Ting
Wang, Xin
Fu, Adan
Xu, Liwen
Lin, Jing
Anxiety and depression predict unfavorable survival in acute myeloid leukemia patients
title Anxiety and depression predict unfavorable survival in acute myeloid leukemia patients
title_full Anxiety and depression predict unfavorable survival in acute myeloid leukemia patients
title_fullStr Anxiety and depression predict unfavorable survival in acute myeloid leukemia patients
title_full_unstemmed Anxiety and depression predict unfavorable survival in acute myeloid leukemia patients
title_short Anxiety and depression predict unfavorable survival in acute myeloid leukemia patients
title_sort anxiety and depression predict unfavorable survival in acute myeloid leukemia patients
topic 4800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824643/
https://www.ncbi.nlm.nih.gov/pubmed/31651837
http://dx.doi.org/10.1097/MD.0000000000017314
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