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β-3 adrenergic receptor gene polymorphisms are associated with gestational diabetes mellitus in a Chinese population

Increasing studies demonstrated that genetic susceptibility attributes to the development of gestational diabetes mellitus (GDM). The polymorphisms of the β-3 adrenergic receptor(β-3AR) gene have been found to be of great importance in bodyweight elevation and dyslipidaemias. We aimed to determine t...

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Autores principales: Jia, He, Pan, Yuan, Wang, Yun, Yin, Feng-Ling, Xu, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824659/
https://www.ncbi.nlm.nih.gov/pubmed/31651836
http://dx.doi.org/10.1097/MD.0000000000017258
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author Jia, He
Pan, Yuan
Wang, Yun
Yin, Feng-Ling
Xu, Na
author_facet Jia, He
Pan, Yuan
Wang, Yun
Yin, Feng-Ling
Xu, Na
author_sort Jia, He
collection PubMed
description Increasing studies demonstrated that genetic susceptibility attributes to the development of gestational diabetes mellitus (GDM). The polymorphisms of the β-3 adrenergic receptor(β-3AR) gene have been found to be of great importance in bodyweight elevation and dyslipidaemias. We aimed to determine the influence of β-3AR polymorphisms on the GDM risk. Thus, we performed a case-control study including 136 GDM cases and 138 controls to evaluate the relation between the rs201607471 and susceptibility to GDM. Likelihood ratios X(2) analysis showed the distribution of the genotype frequency (rs201607471 in β-3AR gene) was accorded with the Hardy-Weinberg genetic equilibrium. Although no significant association between rs201607471 alleles and GDM susceptibility (Chi-square test, P > .05), we observed that β-3AR gene rs201607471 CT genotype was significantly prevalent in GDM (Chi-square test, P < .05). Moreover, we observed that β-3AR gene rs201607471 C > T was significantly associated with an increased risk of GDM using the recessive model (CC vs CT/TT: P = .026) and the additive model (CC vs CT vs TT: P = .038). These data indicate that β-3AR rs201607471 may be a helpful susceptibility marker for GDM in Chinese pregnant women.
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spelling pubmed-68246592019-11-19 β-3 adrenergic receptor gene polymorphisms are associated with gestational diabetes mellitus in a Chinese population Jia, He Pan, Yuan Wang, Yun Yin, Feng-Ling Xu, Na Medicine (Baltimore) 5600 Increasing studies demonstrated that genetic susceptibility attributes to the development of gestational diabetes mellitus (GDM). The polymorphisms of the β-3 adrenergic receptor(β-3AR) gene have been found to be of great importance in bodyweight elevation and dyslipidaemias. We aimed to determine the influence of β-3AR polymorphisms on the GDM risk. Thus, we performed a case-control study including 136 GDM cases and 138 controls to evaluate the relation between the rs201607471 and susceptibility to GDM. Likelihood ratios X(2) analysis showed the distribution of the genotype frequency (rs201607471 in β-3AR gene) was accorded with the Hardy-Weinberg genetic equilibrium. Although no significant association between rs201607471 alleles and GDM susceptibility (Chi-square test, P > .05), we observed that β-3AR gene rs201607471 CT genotype was significantly prevalent in GDM (Chi-square test, P < .05). Moreover, we observed that β-3AR gene rs201607471 C > T was significantly associated with an increased risk of GDM using the recessive model (CC vs CT/TT: P = .026) and the additive model (CC vs CT vs TT: P = .038). These data indicate that β-3AR rs201607471 may be a helpful susceptibility marker for GDM in Chinese pregnant women. Wolters Kluwer Health 2019-10-25 /pmc/articles/PMC6824659/ /pubmed/31651836 http://dx.doi.org/10.1097/MD.0000000000017258 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5600
Jia, He
Pan, Yuan
Wang, Yun
Yin, Feng-Ling
Xu, Na
β-3 adrenergic receptor gene polymorphisms are associated with gestational diabetes mellitus in a Chinese population
title β-3 adrenergic receptor gene polymorphisms are associated with gestational diabetes mellitus in a Chinese population
title_full β-3 adrenergic receptor gene polymorphisms are associated with gestational diabetes mellitus in a Chinese population
title_fullStr β-3 adrenergic receptor gene polymorphisms are associated with gestational diabetes mellitus in a Chinese population
title_full_unstemmed β-3 adrenergic receptor gene polymorphisms are associated with gestational diabetes mellitus in a Chinese population
title_short β-3 adrenergic receptor gene polymorphisms are associated with gestational diabetes mellitus in a Chinese population
title_sort β-3 adrenergic receptor gene polymorphisms are associated with gestational diabetes mellitus in a chinese population
topic 5600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824659/
https://www.ncbi.nlm.nih.gov/pubmed/31651836
http://dx.doi.org/10.1097/MD.0000000000017258
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