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ABCG5/G8: a structural view to pathophysiology of the hepatobiliary cholesterol secretion

The ABCG5/G8 heterodimer is the primary neutral sterol transporter in hepatobiliary and transintestinal cholesterol excretion. Inactivating mutations on either the ABCG5 or ABCG8 subunit cause Sitosterolemia, a rare genetic disorder. In 2016, a crystal structure of human ABCG5/G8 in an apo state sho...

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Detalles Bibliográficos
Autores principales:	Zein, Aiman A., Kaur, Rupinder, Hussein, Toka O.K., Graf, Gregory A., Lee, Jyh-Yeuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2019
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824678/ https://www.ncbi.nlm.nih.gov/pubmed/31654053 http://dx.doi.org/10.1042/BST20190130

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