Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

The serum- and glucocorticoid-regulated kinase (SGK) isoforms contribute resistance to cancer therapies targeting the PI3K pathway. SGKs are homologous to Akt and these kinases display overlapping specificity and phosphorylate several substrates at the same residues, such as TSC2 to promote tumor gr...

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Detalles Bibliográficos
Autores principales: Malik, Nazma, Nirujogi, Raja S., Peltier, Julien, Macartney, Thomas, Wightman, Melanie, Prescott, Alan R., Gourlay, Robert, Trost, Matthias, Alessi, Dario R., Karapetsas, Athanasios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824681/
https://www.ncbi.nlm.nih.gov/pubmed/31665227
http://dx.doi.org/10.1042/BCJ20190608

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