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Poststroke depression and risk of recurrent stroke: A meta-analysis of prospective studies

BACKGROUND: Conflicting results have been reported on the association of poststroke depression with recurrent stroke events. This meta-analysis of prospective studies aims to evaluate whether poststroke depression is an independent predictor of stroke recurrence among stroke patients. METHODS: A sys...

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Autores principales: Wu, Quan-e, Zhou, Ai-min, Han, Yun-peng, Liu, Yan-ming, Yang, Yang, Wang, Xiao-meng, Shi, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824697/
https://www.ncbi.nlm.nih.gov/pubmed/31626084
http://dx.doi.org/10.1097/MD.0000000000017235
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author Wu, Quan-e
Zhou, Ai-min
Han, Yun-peng
Liu, Yan-ming
Yang, Yang
Wang, Xiao-meng
Shi, Xin
author_facet Wu, Quan-e
Zhou, Ai-min
Han, Yun-peng
Liu, Yan-ming
Yang, Yang
Wang, Xiao-meng
Shi, Xin
author_sort Wu, Quan-e
collection PubMed
description BACKGROUND: Conflicting results have been reported on the association of poststroke depression with recurrent stroke events. This meta-analysis of prospective studies aims to evaluate whether poststroke depression is an independent predictor of stroke recurrence among stroke patients. METHODS: A systematic search of articles in PubMed and Embase databases from their inception to October 2018 was conducted. Prospective studies reporting risk estimates of stroke recurrence by depression status in stroke patients were included and pooled risk ratio (RR) with 95% confidence intervals (CIs) of stroke recurrence was calculated for patients with or without poststroke depression. RESULTS: Six studies with 4648 stroke patients were finally included, and the prevalence of poststroke depression was found to from 15.9% to 40.5%. The pooled adjusted RR for stroke recurrence in patients suffering from poststroke depression was 1.48 (1.22–1.79) in a fixed-effect model. Subgroup analyses indicated that poststroke depression significantly increased stroke recurrence (RR 1.64; 95% CI, 1.28–2.10) among ischemic stroke patients but not in total stroke patients (RR 1.28; 95% CI, 0.96–1.73). CONCLUSIONS: This meta-analysis suggests that poststroke depression may be an independent predictor of stroke recurrence among ischemic stroke patients. Further studies are required to investigate whether treatment of poststroke depression can reduce the risk of stroke recurrence.
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spelling pubmed-68246972019-11-19 Poststroke depression and risk of recurrent stroke: A meta-analysis of prospective studies Wu, Quan-e Zhou, Ai-min Han, Yun-peng Liu, Yan-ming Yang, Yang Wang, Xiao-meng Shi, Xin Medicine (Baltimore) 3400 BACKGROUND: Conflicting results have been reported on the association of poststroke depression with recurrent stroke events. This meta-analysis of prospective studies aims to evaluate whether poststroke depression is an independent predictor of stroke recurrence among stroke patients. METHODS: A systematic search of articles in PubMed and Embase databases from their inception to October 2018 was conducted. Prospective studies reporting risk estimates of stroke recurrence by depression status in stroke patients were included and pooled risk ratio (RR) with 95% confidence intervals (CIs) of stroke recurrence was calculated for patients with or without poststroke depression. RESULTS: Six studies with 4648 stroke patients were finally included, and the prevalence of poststroke depression was found to from 15.9% to 40.5%. The pooled adjusted RR for stroke recurrence in patients suffering from poststroke depression was 1.48 (1.22–1.79) in a fixed-effect model. Subgroup analyses indicated that poststroke depression significantly increased stroke recurrence (RR 1.64; 95% CI, 1.28–2.10) among ischemic stroke patients but not in total stroke patients (RR 1.28; 95% CI, 0.96–1.73). CONCLUSIONS: This meta-analysis suggests that poststroke depression may be an independent predictor of stroke recurrence among ischemic stroke patients. Further studies are required to investigate whether treatment of poststroke depression can reduce the risk of stroke recurrence. Wolters Kluwer Health 2019-10-18 /pmc/articles/PMC6824697/ /pubmed/31626084 http://dx.doi.org/10.1097/MD.0000000000017235 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 3400
Wu, Quan-e
Zhou, Ai-min
Han, Yun-peng
Liu, Yan-ming
Yang, Yang
Wang, Xiao-meng
Shi, Xin
Poststroke depression and risk of recurrent stroke: A meta-analysis of prospective studies
title Poststroke depression and risk of recurrent stroke: A meta-analysis of prospective studies
title_full Poststroke depression and risk of recurrent stroke: A meta-analysis of prospective studies
title_fullStr Poststroke depression and risk of recurrent stroke: A meta-analysis of prospective studies
title_full_unstemmed Poststroke depression and risk of recurrent stroke: A meta-analysis of prospective studies
title_short Poststroke depression and risk of recurrent stroke: A meta-analysis of prospective studies
title_sort poststroke depression and risk of recurrent stroke: a meta-analysis of prospective studies
topic 3400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824697/
https://www.ncbi.nlm.nih.gov/pubmed/31626084
http://dx.doi.org/10.1097/MD.0000000000017235
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