Targeting centrosome amplification, an Achilles' heel of cancer

Due to cell-cycle dysregulation, many cancer cells contain more than the normal compliment of centrosomes, a state referred to as centrosome amplification (CA). CA can drive oncogenic phenotypes and indeed can cause cancer in flies and mammals. However, cells have to actively manage CA, often by cen...

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Detalles Bibliográficos
Autores principales: Sabat-Pośpiech, Dorota, Fabian-Kolpanowicz, Kim, Prior, Ian A., Coulson, Judy M., Fielding, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824836/
https://www.ncbi.nlm.nih.gov/pubmed/31506331
http://dx.doi.org/10.1042/BST20190034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824836/
https://www.ncbi.nlm.nih.gov/pubmed/31506331
http://dx.doi.org/10.1042/BST20190034

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