Cargando…

Independent representations of ipsilateral and contralateral limbs in primary motor cortex

Several lines of research demonstrate that primary motor cortex (M1) is principally involved in controlling the contralateral side of the body. However, M1 activity has been correlated with both contralateral and ipsilateral limb movements. Why does ipsilaterally-related activity not cause contralat...

Descripción completa

Detalles Bibliográficos
Autores principales: Heming, Ethan A, Cross, Kevin P, Takei, Tomohiko, Cook, Douglas J, Scott, Stephen H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824843/
https://www.ncbi.nlm.nih.gov/pubmed/31625506
http://dx.doi.org/10.7554/eLife.48190
_version_ 1783464812586467328
author Heming, Ethan A
Cross, Kevin P
Takei, Tomohiko
Cook, Douglas J
Scott, Stephen H
author_facet Heming, Ethan A
Cross, Kevin P
Takei, Tomohiko
Cook, Douglas J
Scott, Stephen H
author_sort Heming, Ethan A
collection PubMed
description Several lines of research demonstrate that primary motor cortex (M1) is principally involved in controlling the contralateral side of the body. However, M1 activity has been correlated with both contralateral and ipsilateral limb movements. Why does ipsilaterally-related activity not cause contralateral motor output? To address this question, we trained monkeys to counter mechanical loads applied to their right and left limbs. We found >50% of M1 neurons had load-related activity for both limbs. Contralateral loads evoked changes in activity ~10ms sooner than ipsilateral loads. We also found corresponding population activities were distinct, with contralateral activity residing in a subspace that was orthogonal to the ipsilateral activity. Thus, neural responses for the contralateral limb can be extracted without interference from the activity for the ipsilateral limb, and vice versa. Our results show that M1 activity unrelated to downstream motor targets can be segregated from activity related to the downstream motor output.
format Online
Article
Text
id pubmed-6824843
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher eLife Sciences Publications, Ltd
record_format MEDLINE/PubMed
spelling pubmed-68248432019-11-04 Independent representations of ipsilateral and contralateral limbs in primary motor cortex Heming, Ethan A Cross, Kevin P Takei, Tomohiko Cook, Douglas J Scott, Stephen H eLife Neuroscience Several lines of research demonstrate that primary motor cortex (M1) is principally involved in controlling the contralateral side of the body. However, M1 activity has been correlated with both contralateral and ipsilateral limb movements. Why does ipsilaterally-related activity not cause contralateral motor output? To address this question, we trained monkeys to counter mechanical loads applied to their right and left limbs. We found >50% of M1 neurons had load-related activity for both limbs. Contralateral loads evoked changes in activity ~10ms sooner than ipsilateral loads. We also found corresponding population activities were distinct, with contralateral activity residing in a subspace that was orthogonal to the ipsilateral activity. Thus, neural responses for the contralateral limb can be extracted without interference from the activity for the ipsilateral limb, and vice versa. Our results show that M1 activity unrelated to downstream motor targets can be segregated from activity related to the downstream motor output. eLife Sciences Publications, Ltd 2019-10-18 /pmc/articles/PMC6824843/ /pubmed/31625506 http://dx.doi.org/10.7554/eLife.48190 Text en © 2019, Heming et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Heming, Ethan A
Cross, Kevin P
Takei, Tomohiko
Cook, Douglas J
Scott, Stephen H
Independent representations of ipsilateral and contralateral limbs in primary motor cortex
title Independent representations of ipsilateral and contralateral limbs in primary motor cortex
title_full Independent representations of ipsilateral and contralateral limbs in primary motor cortex
title_fullStr Independent representations of ipsilateral and contralateral limbs in primary motor cortex
title_full_unstemmed Independent representations of ipsilateral and contralateral limbs in primary motor cortex
title_short Independent representations of ipsilateral and contralateral limbs in primary motor cortex
title_sort independent representations of ipsilateral and contralateral limbs in primary motor cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824843/
https://www.ncbi.nlm.nih.gov/pubmed/31625506
http://dx.doi.org/10.7554/eLife.48190
work_keys_str_mv AT hemingethana independentrepresentationsofipsilateralandcontralaterallimbsinprimarymotorcortex
AT crosskevinp independentrepresentationsofipsilateralandcontralaterallimbsinprimarymotorcortex
AT takeitomohiko independentrepresentationsofipsilateralandcontralaterallimbsinprimarymotorcortex
AT cookdouglasj independentrepresentationsofipsilateralandcontralaterallimbsinprimarymotorcortex
AT scottstephenh independentrepresentationsofipsilateralandcontralaterallimbsinprimarymotorcortex