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Independent representations of ipsilateral and contralateral limbs in primary motor cortex
Several lines of research demonstrate that primary motor cortex (M1) is principally involved in controlling the contralateral side of the body. However, M1 activity has been correlated with both contralateral and ipsilateral limb movements. Why does ipsilaterally-related activity not cause contralat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824843/ https://www.ncbi.nlm.nih.gov/pubmed/31625506 http://dx.doi.org/10.7554/eLife.48190 |
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author | Heming, Ethan A Cross, Kevin P Takei, Tomohiko Cook, Douglas J Scott, Stephen H |
author_facet | Heming, Ethan A Cross, Kevin P Takei, Tomohiko Cook, Douglas J Scott, Stephen H |
author_sort | Heming, Ethan A |
collection | PubMed |
description | Several lines of research demonstrate that primary motor cortex (M1) is principally involved in controlling the contralateral side of the body. However, M1 activity has been correlated with both contralateral and ipsilateral limb movements. Why does ipsilaterally-related activity not cause contralateral motor output? To address this question, we trained monkeys to counter mechanical loads applied to their right and left limbs. We found >50% of M1 neurons had load-related activity for both limbs. Contralateral loads evoked changes in activity ~10ms sooner than ipsilateral loads. We also found corresponding population activities were distinct, with contralateral activity residing in a subspace that was orthogonal to the ipsilateral activity. Thus, neural responses for the contralateral limb can be extracted without interference from the activity for the ipsilateral limb, and vice versa. Our results show that M1 activity unrelated to downstream motor targets can be segregated from activity related to the downstream motor output. |
format | Online Article Text |
id | pubmed-6824843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-68248432019-11-04 Independent representations of ipsilateral and contralateral limbs in primary motor cortex Heming, Ethan A Cross, Kevin P Takei, Tomohiko Cook, Douglas J Scott, Stephen H eLife Neuroscience Several lines of research demonstrate that primary motor cortex (M1) is principally involved in controlling the contralateral side of the body. However, M1 activity has been correlated with both contralateral and ipsilateral limb movements. Why does ipsilaterally-related activity not cause contralateral motor output? To address this question, we trained monkeys to counter mechanical loads applied to their right and left limbs. We found >50% of M1 neurons had load-related activity for both limbs. Contralateral loads evoked changes in activity ~10ms sooner than ipsilateral loads. We also found corresponding population activities were distinct, with contralateral activity residing in a subspace that was orthogonal to the ipsilateral activity. Thus, neural responses for the contralateral limb can be extracted without interference from the activity for the ipsilateral limb, and vice versa. Our results show that M1 activity unrelated to downstream motor targets can be segregated from activity related to the downstream motor output. eLife Sciences Publications, Ltd 2019-10-18 /pmc/articles/PMC6824843/ /pubmed/31625506 http://dx.doi.org/10.7554/eLife.48190 Text en © 2019, Heming et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Heming, Ethan A Cross, Kevin P Takei, Tomohiko Cook, Douglas J Scott, Stephen H Independent representations of ipsilateral and contralateral limbs in primary motor cortex |
title | Independent representations of ipsilateral and contralateral limbs in primary motor cortex |
title_full | Independent representations of ipsilateral and contralateral limbs in primary motor cortex |
title_fullStr | Independent representations of ipsilateral and contralateral limbs in primary motor cortex |
title_full_unstemmed | Independent representations of ipsilateral and contralateral limbs in primary motor cortex |
title_short | Independent representations of ipsilateral and contralateral limbs in primary motor cortex |
title_sort | independent representations of ipsilateral and contralateral limbs in primary motor cortex |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824843/ https://www.ncbi.nlm.nih.gov/pubmed/31625506 http://dx.doi.org/10.7554/eLife.48190 |
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