A negative feedback regulatory loop between miR-138 and TP53 is mediated by USP10

TP53 is a critical tumor suppressor. In approximately 50% of human cancers the TP53 gene is either lost or mutated. The expression level of TP53 in the cells is tightly controlled by a fine-tune machinery, mainly through the Mdm2-mediated ubiquitination pathway. On the other side, the ubiquitinated...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Zhenghua, Zhang, Manchao, Cui, Ri, Tili, Esmerina, Kim, Taewan, Lee, Tae Jin, Peng, Yong, Croce, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824876/
https://www.ncbi.nlm.nih.gov/pubmed/31695837
http://dx.doi.org/10.18632/oncotarget.27275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824876/
https://www.ncbi.nlm.nih.gov/pubmed/31695837
http://dx.doi.org/10.18632/oncotarget.27275

Ejemplares similares