Depletion of DNA damage binding protein 2 sensitizes triple‐negative breast cancer cells to poly ADP‐ribose polymerase inhibition by destabilizing Rad51

Poly ADP‐ribose polymerase inhibitors (PARPi) have shown promising therapeutic efficacy in triple‐negative breast cancer (TNBC) patients. However, resistance ultimately develops, preventing a curative effect from being attained. Extensive investigations have indicated the diversity in the mechanisms...

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Detalles Bibliográficos
Autores principales: Zhao, Lin, Si, Cheng‐Shuai, Yu, Yue, Lu, Jian‐Wei, Zhuang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825009/
https://www.ncbi.nlm.nih.gov/pubmed/31541611
http://dx.doi.org/10.1111/cas.14201

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