Degrading products of chondroitin sulfate can induce hypertrophy-like changes and MMP-13/ADAMTS5 production in chondrocytes

Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in articular cartilage and the loss of CS-GAG occurs early in OA. As a major component of perichondral matrix interacting directly with chondrocytes, the active turnover of CS can affect to break the homeostasis of chondrocytes. H...

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Detalles Bibliográficos
Autores principales: Jung, Youn-Kwan, Park, Hye-Ri, Cho, Hyun-Jung, Jang, Ji-Ae, Lee, Eun-Ju, Han, Min-Su, Kim, Gun-Woo, Han, Seungwoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825126/
https://www.ncbi.nlm.nih.gov/pubmed/31676809
http://dx.doi.org/10.1038/s41598-019-52358-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825126/
https://www.ncbi.nlm.nih.gov/pubmed/31676809
http://dx.doi.org/10.1038/s41598-019-52358-4

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