Cryo-EM structure of a transthyretin-derived amyloid fibril from a patient with hereditary ATTR amyloidosis

ATTR amyloidosis is one of the worldwide most abundant forms of systemic amyloidosis. The disease is caused by the misfolding of transthyretin protein and the formation of amyloid deposits at different sites within the body. Here, we present a 2.97 Å cryo electron microscopy structure of a fibril pu...

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Detalles Bibliográficos
Autores principales: Schmidt, Matthias, Wiese, Sebastian, Adak, Volkan, Engler, Jonas, Agarwal, Shubhangi, Fritz, Günter, Westermark, Per, Zacharias, Martin, Fändrich, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825171/
https://www.ncbi.nlm.nih.gov/pubmed/31676763
http://dx.doi.org/10.1038/s41467-019-13038-z

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