Integrated solid-state NMR and molecular dynamics modeling determines membrane insertion of human β-defensin analog

Human β-defensins (hBD) play central roles in antimicrobial activities against various microorganisms and in immune-regulation. These peptides perturb phospholipid membranes for function, but it is not well understood how defensins approach, insert and finally disrupt membranes on the molecular leve...

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Detalles Bibliográficos
Autores principales: Kang, Xue, Elson, Christopher, Penfield, Jackson, Kirui, Alex, Chen, Adrian, Zhang, Liqun, Wang, Tuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825183/
https://www.ncbi.nlm.nih.gov/pubmed/31701030
http://dx.doi.org/10.1038/s42003-019-0653-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825183/
https://www.ncbi.nlm.nih.gov/pubmed/31701030
http://dx.doi.org/10.1038/s42003-019-0653-6

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